2015
Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, PMCID: PMC11340030, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIVPopulation-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia
Parham GP, Mwanahamuntu MH, Kapambwe S, Muwonge R, Bateman AC, Blevins M, Chibwesha CJ, Pfaendler KS, Mudenda V, Shibemba AL, Chisele S, Mkumba G, Vwalika B, Hicks ML, Vermund SH, H. BH, Stringer JS, Sankaranarayanan R, Sahasrabuddhe VV. Population-Level Scale-Up of Cervical Cancer Prevention Services in a Low-Resource Setting: Development, Implementation, and Evaluation of the Cervical Cancer Prevention Program in Zambia. PLOS ONE 2015, 10: e0122169. PMID: 25885821, PMCID: PMC4401717, DOI: 10.1371/journal.pone.0122169.Peer-Reviewed Original ResearchConceptsCervical cancer prevention programsCancer prevention programsHistopathologic evaluationCervical intraepithelial neoplasia grade 2Cervical cancer prevention servicesPrevention programsHIV-negative womenInvasive cervical cancerCancer prevention servicesCervical cancer preventionExpert physician opinionHIV/AIDS programsElectronic medical recordsLow-resource countriesProportion of womenSame-day servicesLow-resource settingsUnscreened womenEvaluable dataCervical diseaseCervical cancerScreening servicesMedical recordsCancer preventionCervical precancer
2014
Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia
Bateman AC, Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Kapambwe S, Katundu K, Nkole T, Mulundika J, Pfaendler KS, Hicks ML, Shibemba A, Vermund SH, Stringer JS, Chibwesha CJ. Clinical Performance of Digital Cervicography and Cytology for Cervical Cancer Screening in HIV-Infected Women in Lusaka, Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 212-215. PMID: 24977474, PMCID: PMC4162769, DOI: 10.1097/qai.0000000000000270.Peer-Reviewed Original ResearchConceptsClinical performanceDigital cervicographyCervical intraepithelial neoplasia grade 2High-grade squamous intraepithelial lesionsCervical cancer screeningSquamous intraepithelial lesionsIntraepithelial lesionsCancer screeningCervicographyGrade 2HIVCytologyWomenLesionsVisual inspectionSpecificity
2012
HPV Genotype Distribution in Cervical Intraepithelial Neoplasia among HIV-Infected Women in Pune, India
Mane A, Nirmalkar A, Risbud AR, Vermund SH, Mehendale SM, Sahasrabuddhe VV. HPV Genotype Distribution in Cervical Intraepithelial Neoplasia among HIV-Infected Women in Pune, India. PLOS ONE 2012, 7: e38731. PMID: 22723879, PMCID: PMC3378535, DOI: 10.1371/journal.pone.0038731.Peer-Reviewed Original ResearchConceptsCarcinogenic HPV genotypesHPV genotypesLow CD4HPV infectionCIN3 lesionsCommon HPV genotypesHPV genotype distributionMultiple HPV genotypesCombination antiretroviral therapyCervical intraepithelial neoplasiaCarcinogenic HPV infectionHalf of womenQuarter of womenHPV type detectionLifetime sexual partnersCarcinogenic HPVHPV16 detectionAntiretroviral therapyHPV genotypingComposite endpointOrder of prevalenceIntraepithelial neoplasiaCervical cancerHPV 16Observational study
2011
Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program
2010
Prevalence and Predictors of Colposcopic-Histopathologically Confirmed Cervical Intraepithelial Neoplasia in HIV-Infected Women in India
Sahasrabuddhe VV, Bhosale RA, Joshi SN, Kavatkar AN, Nagwanshi CA, Kelkar RS, Jenkins CA, Shepherd BE, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Prevalence and Predictors of Colposcopic-Histopathologically Confirmed Cervical Intraepithelial Neoplasia in HIV-Infected Women in India. PLOS ONE 2010, 5: e8634. PMID: 20072610, PMCID: PMC2798747, DOI: 10.1371/journal.pone.0008634.Peer-Reviewed Original ResearchConceptsCervical intraepithelial neoplasiaCervical high-risk HPV DNASeverity of CINHigh-risk HPV DNAAntiretroviral therapyHPV DNAIndependent predictorsIntraepithelial neoplasiaCervical cancerEvidence of CINPrevalence of CINPrevalence estimatesMultivariable ordinal logistic regression analysisMultivariable ordinal logistic regressionAdvanced neoplastic diseaseNon-pregnant HIVTrue disease burdenCervical precancerous lesionsLogistic regression analysisOrdinal logistic regression analysisClinical suspicionCIN1 lesionsMedian agePreventable cancersCervical cytology
2009
Human Immunodeficiency Virus (HIV) Antigens and RNA in HIV-Seronegative Women with Cervical Intraepithelial Neoplasia
Basu J, Romney SL, Angeletti RH, Vermund SH, Nieves E, Kadish AS, Mikhail MS, Orr GA. Human Immunodeficiency Virus (HIV) Antigens and RNA in HIV-Seronegative Women with Cervical Intraepithelial Neoplasia. AIDS Research And Human Retroviruses 2009, 25: 249-259. PMID: 19292595, PMCID: PMC6463994, DOI: 10.1089/aid.2008.0096.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHIVHIV AntibodiesHIV AntigensHIV InfectionsHumansRNA, ViralUterine Cervical DysplasiaVaginaVaginal DouchingConceptsCervical intraepithelial neoplasiaProstate-specific antigenCervicovaginal lavageHIV proteinsIntraepithelial neoplasiaWestern blotHuman immunodeficiency virus antigenHIV p24 expressionHIV-2 antibodiesHIV-seronegative womenRisk of progressionViral load assaysCervical biopsy specimensHIV serologySeronegative womenHIV RNAHIV exposureCervical secretionsHIV antigenNegative serologyP24 antigenCervical cancerBiopsy specimensP24 expressionVirus antigen
2006
Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Shepherd BE, Hicks ML, Stringer EM, Vermund SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecologic Oncology 2006, 103: 1017-1022. PMID: 16875716, PMCID: PMC2748907, DOI: 10.1016/j.ygyno.2006.06.015.Peer-Reviewed Original ResearchConceptsHigh-risk HPV typesSquamous intraepithelial lesionsSquamous cell carcinomaHPV typesIntraepithelial lesionsHIV/AIDS care servicesPrevalence of SILHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsCervical squamous intraepithelial lesionsMultivariable logistic regression modelingNon-pregnant HIVScreening of HIVDevelopment of HPVLogistic regression modelingResource-constrained settingsResource-constrained nationsMedian CD4Abnormal cytologyAntiretroviral therapyCytological lesionsHPV typingIndependent predictorsMedian ageCervical cancer
2003
Utility of cervicography in HIV-infected and uninfected adolescents
Moscicki AB, Durako SJ, Ma Y, Darragh T, Vermund SH. Utility of cervicography in HIV-infected and uninfected adolescents. Journal Of Adolescent Health 2003, 32: 204-213. PMID: 12606114, DOI: 10.1016/s1054-139x(02)00461-5.Peer-Reviewed Original ResearchConceptsPositive predictive valuePap smearUninfected groupHigh-risk adolescent populationAdequate Pap smearsLow positive predictive valueRepeat Papanicolaou smearsSingle Pap smearVisit 6 monthsHIV-positive youthHIV-negative youthPositive cervigramHIV infectionCervical cancerProspective studyVisit 1Papanicolaou smearsUninfected adolescentsHIVPredictive valueTime of analysisAdolescent populationCervicography
2000
Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls: Impact of Infection With Human Immunodeficiency Virus
Moscicki AB, Ellenberg JH, Vermund SH, Holland CA, Darragh T, Crowley-Nowick PA, Levin L, Wilson CM. Prevalence of and Risks for Cervical Human Papillomavirus Infection and Squamous Intraepithelial Lesions in Adolescent Girls: Impact of Infection With Human Immunodeficiency Virus. JAMA Pediatrics 2000, 154: 127-134. PMID: 10665598, DOI: 10.1001/archpedi.154.2.127.Peer-Reviewed Original ResearchConceptsSquamous intraepithelial lesionsHPV infectionHuman papillomavirus infectionIntraepithelial lesionsPapillomavirus infectionHIV infectionHIV statusCervical human papillomavirus infectionLow-risk HPV typesCourse of HIVNormal cytologic findingsCD4 cell countCervical HPV infectionT-cell countsT-cell immunosuppressionHuman immunodeficiency virusHigh-risk typesAdolescent girlsSexual risk behaviorsImpact of infectionCD4 immunosuppressionBaseline visitHPV typesRisky sexual behaviorViral load
1994
Risk Factors For Squamous Intraepithelial Lesions On Pap Smear In Women At Risk For Human Immunodeficiency Virus Infection
Klein R, Ho G, Vermund S, Fleming I, Burk R. Risk Factors For Squamous Intraepithelial Lesions On Pap Smear In Women At Risk For Human Immunodeficiency Virus Infection. The Journal Of Infectious Diseases 1994, 170: 1404-1409. PMID: 7995978, DOI: 10.1093/infdis/170.6.1404.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellCD4 Lymphocyte CountDNA, ViralFemaleHIV AntibodiesHIV InfectionsHumansImmunocompromised HostMiddle AgedMultivariate AnalysisNew YorkOdds RatioPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPrevalenceRisk FactorsTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsSquamous intraepithelial lesionsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionRisk factorsHPV infectionHIV infectionIntraepithelial lesionsPap smearVirus infectionHigh-risk HPV typesGenital HPV infectionHIV antibody testingIndependent risk factorSevere HIVSevere immunosuppressionHPV typesAntibody testingGenital HPVUnivariate analysisMultivariate analysisInfectionGenome detectionImmunosuppressionRiskLesions
1993
Alterations in Erythrocyte Glutathione Metabolism Associated with Cervical Dysplasias and Carcinoma in Situ
Basu J, Duttagupta C, Vermund S, Ahn C, Palan P, Romney S. Alterations in Erythrocyte Glutathione Metabolism Associated with Cervical Dysplasias and Carcinoma in Situ. Cancer Investigation 1993, 11: 652-659. PMID: 8221197, DOI: 10.3109/07357909309046937.Peer-Reviewed Original ResearchConceptsCervical dysplasiaSevere dysplasiaPeripheral venous blood samplesCervical dysplastic lesionsSeverity of dysplasiaVenous blood samplesErythrocyte glutathione levelsErythrocyte glutathione metabolismPap testCervical abnormalitiesModerate dysplasiaCervical lesionsSevere gradesDysplastic lesionsErythrocyte levelsHistopathological diagnosisBlood samplesGlutathione reductaseDysplasiaGlutathione levelsReduced glutathioneGlucose-6-phosphate dehydrogenaseCarcinomaLesionsMultiple pairwise comparisons
1991
Human papillomavirus, gonorrhea, syphilis, and cervical dysplasia in jailed women.
Bickell NA, Vermund SH, Holmes M, Safyer S, Burk RD. Human papillomavirus, gonorrhea, syphilis, and cervical dysplasia in jailed women. American Journal Of Public Health 1991, 81: 1318-20. PMID: 1928533, PMCID: PMC1405301, DOI: 10.2105/ajph.81.10.1318.Peer-Reviewed Original ResearchConceptsHuman papillomavirusPap smearRoutine intake proceduresAbnormal Pap smearsBehavioral risk factorsNew York City jailsCervicovaginal lavageSerologic syphilisHPV infectionCervical diseaseCervical dysplasiaCervical cytologyRisk factorsIntake proceduresFemale detaineesWomenPapillomavirusSyphilisHigh rateCity jailsDiseaseSmearsIncarcerated womenLavageGonorrheaPlasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia.
Basu J, Palan PR, Vermund SH, Goldberg GL, Burk RD, Romney SL. Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia. Cancer Epidemiology 1991, 15: 165-70. PMID: 1647869.Peer-Reviewed Original ResearchConceptsBeta-carotene levelsHPV infectionCervical dysplasiaClinical statusPap smearPeripheral venous blood samplesImportance of smokingRepeat Pap smearHuman papillomavirus infectionAbnormal Pap smearsVenous blood samplesGrades of severityPlasma ascorbic acidAscorbic acid levelsCervix dysplasiaColposcopy clinicHPV statusPapillomavirus infectionLavage specimenPlasma levelsMean plasmaDysplastic groupBlood samplesDysplasiaSmoking
1988
Decreased Plasma β-Carotene Levels in Women With Uterine Cervical Dysplasias and Cancer1
PALAN P, ROMNEY S, MIKHAIL M, BASU J, VERMUND S. Decreased Plasma β-Carotene Levels in Women With Uterine Cervical Dysplasias and Cancer1. Journal Of The National Cancer Institute 1988, 80: 454-455. PMID: 3367386, DOI: 10.1093/jnci/80.6.454.Peer-Reviewed Original Research
1987
Plasma Reduced and Total Ascorbic Acid in Human Uterine Cervix Dysplasias and Cancer
ROMNEY S, BASU J, VERMUND S, PALAN P, DUTTAGUPTA C. Plasma Reduced and Total Ascorbic Acid in Human Uterine Cervix Dysplasias and Cancer. Annals Of The New York Academy Of Sciences 1987, 498: 132-143. PMID: 3475995, DOI: 10.1111/j.1749-6632.1987.tb23757.x.Peer-Reviewed Original ResearchAscorbic AcidBiopsyCarcinoma in SituFemaleHumansHysterectomyUterine Cervical DysplasiaUterine Cervical Neoplasms