Tumor Infiltrating Lymphocytes Target HLA-I Phosphopeptides Derived From Cancer Signaling in Colorectal Cancer
Penny SA, Abelin JG, Malaker SA, Myers PT, Saeed AZ, Steadman LG, Bai DL, Ward ST, Shabanowitz J, Hunt DF, Cobbold M. Tumor Infiltrating Lymphocytes Target HLA-I Phosphopeptides Derived From Cancer Signaling in Colorectal Cancer. Frontiers In Immunology 2021, 12: 723566. PMID: 34504498, PMCID: PMC8421858, DOI: 10.3389/fimmu.2021.723566.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesCell Line, TumorColorectal NeoplasmsHistocompatibility Antigens Class IHumansLymphocytes, Tumor-InfiltratingPhosphopeptidesT-Lymphocytes, CytotoxicConceptsT cell responsesColorectal cancerCRC patientsPatient tumorsTumor antigensCell responsesPeripheral T cell responsesCytotoxic T-cell infiltrationFuture immunotherapeutic strategiesCRC liver metastasesNovel immunotherapeutic targetT cell infiltrationTumor-Infiltrating LymphocytesTumor-specific antigensPrimary CRC tumorsCRC cell linesKey prognostic indicatorMarker of malignancyCRC patient tumorsMultifunctional CD8Immunotherapeutic strategiesLiver metastasesInfiltrating lymphocytesCytokine responsesSame HLA