2020
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Baptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores CM, Ghosh S, Nunes-de-Souza R, Canto-de-Souza A, Price TJ. Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model. Neurobiology Of Pain 2020, 8: 100049. PMID: 32548337, PMCID: PMC7284072, DOI: 10.1016/j.ynpai.2020.100049.Peer-Reviewed Original ResearchHyperalgesic primingPlantar incisionFemale miceBasolateral nucleusHyperalgesic priming modelSucrose splash testSex differencesPain-related behaviorsIntra-BLA microinjectionGluA2-containing AMPA receptorsDistinct brain regionsMechanical hypersensitivityPain mechanismsAberrant behavioral responsesChronic painFacial grimacingBody of evidenceMale miceSplash testPain unpleasantnessProstaglandin EAMPA receptorsGluA2 expressionUnderlying neural mechanismsBrain regions
2014
Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity
Melemedjian OK, Tillu DV, Moy JK, Asiedu MN, Mandell EK, Ghosh S, Dussor G, Price TJ. Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity. Molecular Pain 2014, 10: 1744-8069-10-45. PMID: 24993495, PMCID: PMC4091745, DOI: 10.1186/1744-8069-10-45.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonal TransportBrain-Derived Neurotrophic FactorCells, CulturedColchicineCREB-Binding ProteinDisease Models, AnimalGanglia, SpinalGene Expression RegulationInterleukin-6MaleMiceMice, Inbred ICRNociceptive PainNocodazoleProtein TransportQuinazolinonesSciatic NerveSensory Receptor CellsTubulin ModulatorsConceptsCyclic AMP response element binding proteinDorsal root gangliaInterleukin-6Retrograde axonal transportNerve growth factorHyperalgesic primingMechanical hypersensitivityAxonal transportNociceptive plasticitySensory neuronsRetrograde transportExpression of BDNFPrimary sensory neuronsExpression of CREBHr post injectionIL-6 treatmentAxonal traffickingActivity-dependent translationAMP response element binding proteinResponse element-binding proteinCREB DNA bindingIntrathecal injectionHindpaw injectionNociceptive sensitizationInflammatory model