2013
ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain
Price TJ, Ghosh S. ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain. Molecular Pain 2013, 9: 1744-8069-9-6. PMID: 23433248, PMCID: PMC3621284, DOI: 10.1186/1744-8069-9-6.BooksConceptsChronic pain statesChronic painLong-term potentiationAnterior cingulate cortexPain statesPain plasticityCertain chronic pain statesRole of PKMζSpinal dorsal hornChronic pain developmentSignificant clinical problemPotential roleSuch off-target effectsPain reliefDorsal hornPain developmentCNS areasCNS regionsClinical problemNociceptor stimulationPainCingulate cortexNew targetsKey moleculesOff-target effects
2012
Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain
King T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain 2012, 153: 1263-1273. PMID: 22482911, PMCID: PMC3358498, DOI: 10.1016/j.pain.2012.03.006.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexExperimental neuropathic painNeuropathic painMK-801Spontaneous painN-methyl-D-aspartate receptor blockadeSpinal nerve ligation injuryNerve ligation injurySpinal dorsal hornLong-term potentiationAnterior cingulate cortexPseudosubstrate inhibitory peptideDorsal hornReceptor blockadeTime-dependent mannerLigation injuryPain processingSingle administrationSpinal cordPainCingulate cortexFull recoveryInhibitory peptidesInhibition of PKMζIndependent mechanisms