2011
Human annulus fibrosus material properties from biaxial testing and constitutive modeling are altered with degeneration
O’Connell G, Sen S, Elliott DM. Human annulus fibrosus material properties from biaxial testing and constitutive modeling are altered with degeneration. Biomechanics And Modeling In Mechanobiology 2011, 11: 493-503. PMID: 21748426, PMCID: PMC3500512, DOI: 10.1007/s10237-011-0328-9.Peer-Reviewed Original ResearchAxial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration
O’Connell G, Jacobs NT, Sen S, Vresilovic EJ, Elliott DM. Axial creep loading and unloaded recovery of the human intervertebral disc and the effect of degeneration. Journal Of The Mechanical Behavior Of Biomedical Materials 2011, 4: 933-942. PMID: 21783103, PMCID: PMC3143379, DOI: 10.1016/j.jmbbm.2011.02.002.Peer-Reviewed Original Research
2010
Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement. Spine 2010, 35: 867-873. PMID: 20354467, PMCID: PMC3421837, DOI: 10.1097/brs.0b013e3181d74414.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBiomechanical PhenomenaCattleCells, CulturedCompressive StrengthExtracellular MatrixFibrocartilageHumansHydrogelsIntervertebral DiscIntervertebral Disc DisplacementMaterials TestingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNanofibersProsthesis DesignSepharoseTissue EngineeringTissue ScaffoldsWeight-Bearing
2009
Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus
Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials 2009, 8: 986-992. PMID: 19855383, PMCID: PMC3415301, DOI: 10.1038/nmat2558.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiocompatible MaterialsCattleCollagenExtracellular MatrixIntervertebral DiscMesenchymal Stem CellsNanostructuresTissue EngineeringConceptsMulti-scale structural hierarchyAnnulus fibrosus tissue engineeringTissue engineering applicationsLoad-bearing tissuesTensile responseEngineering applicationsTissue engineeringLaminatesBiomimetic materialsComplex mechanical functionsNative tissueStructural hierarchySuccessful engineeringEngineeringScaffoldsAnnulus fibrosusGreat interestShearingMechanical functionComplex tissuesDepositionMaterialsReduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics
Boxberger JI, Orlansky AS, Sen S, Elliott DM. Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics. Journal Of Biomechanics 2009, 42: 1941-1946. PMID: 19539936, PMCID: PMC2756063, DOI: 10.1016/j.jbiomech.2009.05.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaDiscitisElasticityGlycosaminoglycansIntervertebral DiscPliabilityRatsWeight-BearingConceptsDynamic stiffnessCompressive loadEquilibrium loadHigh dynamic stiffnessDynamic loading regimesPhase angleDynamic viscoelastic propertiesMechanical behaviorAxial loadViscoelastic mechanicsOscillatory loadingLoading regimesLow loadViscoelastic propertiesDynamic mechanicsLumbar motion segmentsMechanical mechanismDisc mechanicsStiffnessLoadSpectrum of frequenciesPossible mechanical mechanismsReduced glycosaminoglycansMotion segmentsMechanics
2008
Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc
Beckstein JC, Sen S, Schaer TP, Vresilovic EJ, Elliott DM. Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc. Spine 2008, 33: e166-e173. PMID: 18344845, DOI: 10.1097/brs.0b013e318166e001.Peer-Reviewed Original ResearchAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks
2006
Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments
Boxberger JI, Sen S, Yerramalli CS, Elliott DM. Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments. Journal Of Orthopaedic Research® 2006, 24: 1906-1915. PMID: 16865712, DOI: 10.1002/jor.20221.Peer-Reviewed Original Research