Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds
Nerurkar NL, Sen S, Baker BM, Elliott DM, Mauck RL. Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds. Acta Biomaterialia 2010, 7: 485-491. PMID: 20728589, PMCID: PMC2994961, DOI: 10.1016/j.actbio.2010.08.011.Peer-Reviewed Original ResearchConceptsTissue engineering applicationsElectrospun scaffoldsNanofibrous scaffoldsEngineering applicationsFiber-reinforced soft tissuesDynamic cultureElectrospun nanofibrous scaffoldsCellular ingressSmall pore sizeDynamic culture conditionsMechanical propertiesScaffold thicknessTensile modulusFree-swelling conditionsPore sizeFree-swelling cultureHeterogeneous depositionDense packingInfiltration resultsIngressScaffoldsKnee meniscusApplicationsModulusSoft tissueEngineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement. Spine 2010, 35: 867-873. PMID: 20354467, PMCID: PMC3421837, DOI: 10.1097/brs.0b013e3181d74414.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBiomechanical PhenomenaCattleCells, CulturedCompressive StrengthExtracellular MatrixFibrocartilageHumansHydrogelsIntervertebral DiscIntervertebral Disc DisplacementMaterials TestingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNanofibersProsthesis DesignSepharoseTissue EngineeringTissue ScaffoldsWeight-Bearing