Featured Publications
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
Lau S, Chen C, Fu W, Qu J, Cheung T, Fu A, Ip N. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease. Cell Reports 2020, 31: 107530. PMID: 32320664, DOI: 10.1016/j.celrep.2020.107530.Peer-Reviewed Original ResearchConceptsTranscriptome profilingAlzheimer's diseaseTranscription factor bindingSignature genesMicroglial state transitionChromatin accessibilityFactor bindingTranscriptome reprogrammingClearance activityBeta-amyloidTranscriptomeAD pathologyMicroglial transcriptomeTranscriptional pathwaysMajor histocompatibility complex classMicroglial subpopulationsTranscriptomic signaturesEnhanced phagocytic activityMicroglial functionHistocompatibility complex classPhagocytic activityAlzheimerInterleukin (IL)-33Activation of microgliaChromatin
2021
Rhynchophylline Administration Ameliorates Amyloid‑β Pathology and Inflammation in an Alzheimer’s Disease Transgenic Mouse Model
Fu W, Hung K, Lau S, Butt B, Yuen V, Fu G, Chan I, Ip F, Fu A, Ip N. Rhynchophylline Administration Ameliorates Amyloid‑β Pathology and Inflammation in an Alzheimer’s Disease Transgenic Mouse Model. ACS Chemical Neuroscience 2021, 12: 4249-4256. PMID: 34738783, DOI: 10.1021/acschemneuro.1c00600.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAPP/PS1 miceAD transgenic mouse modelAlzheimer's disease transgenic mouse modelTransgenic mouse modelUbiquitin-proteasome systemMolecular pathwaysAmyloid plaque burdenProteasome systemTranscriptome analysisAmyloid metabolismRegulating multiple molecular pathwaysDisease-associated pathologyMicroglial functional stateAmyloid pathologyMouse modelNeurodegenerative diseasesAPP/PS1Multiple molecular pathwaysImpaired hippocampal synaptic plasticityPathwayAlzheimerSynaptic plasticityTranscriptomeUbiquitin