Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
Lau S, Cao H, Fu A, Ip N. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 25800-25809. PMID: 32989152, PMCID: PMC7568283, DOI: 10.1073/pnas.2008762117.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptome analysisAngiogenic endothelial cellsAlzheimer's diseaseTranscriptome analysisEndothelial cellsCell type-specific responsesCellular targetsCell type-specific transcriptomic changesNormal controlsIncreased expression of angiogenic growth factorsType-specific responsesTherapeutic developmentAntigen presentation machineryComprehensive molecular profilingSamples of AD patientsAD brainAD pathogenesisDysregulation of endothelial cellsExpression of angiogenic growth factorsDisruption of biological processesTranscriptomic changesPrefrontal cortical samplesBiological processesCellular heterogeneityAngiogenic growth factors