Featured Publications
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
Lau S, Chen C, Fu W, Qu J, Cheung T, Fu A, Ip N. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease. Cell Reports 2020, 31: 107530. PMID: 32320664, DOI: 10.1016/j.celrep.2020.107530.Peer-Reviewed Original ResearchConceptsTranscriptome profilingAlzheimer's diseaseTranscription factor bindingSignature genesMicroglial state transitionChromatin accessibilityFactor bindingTranscriptome reprogrammingClearance activityBeta-amyloidTranscriptomeAD pathologyMicroglial transcriptomeTranscriptional pathwaysMajor histocompatibility complex classMicroglial subpopulationsTranscriptomic signaturesEnhanced phagocytic activityMicroglial functionHistocompatibility complex classPhagocytic activityAlzheimerInterleukin (IL)-33Activation of microgliaChromatin
2021
Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model
Lau S, Wu W, Seo H, Fu A, Ip N. Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse model. STAR Protocols 2021, 2: 100265. PMID: 33490981, PMCID: PMC7811161, DOI: 10.1016/j.xpro.2020.100265.Peer-Reviewed Original ResearchConceptsDeposition of extracellular amyloid-betaDisease mouse modelExtracellular amyloid-betaAlzheimer's disease mouse modelAmyloid-betaFlow cytometry-based methodPhagocytic capacityMicroglial phagocytosisMicroglial subpopulationsAlzheimer's diseaseDownstream applicationsAlzheimerMouse modelPhagocytic microgliaIsolatesPhagocytosis