Featured Publications
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
Lau S, Chen C, Fu W, Qu J, Cheung T, Fu A, Ip N. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease. Cell Reports 2020, 31: 107530. PMID: 32320664, DOI: 10.1016/j.celrep.2020.107530.Peer-Reviewed Original ResearchConceptsTranscriptome profilingAlzheimer's diseaseTranscription factor bindingSignature genesMicroglial state transitionChromatin accessibilityFactor bindingTranscriptome reprogrammingClearance activityBeta-amyloidTranscriptomeAD pathologyMicroglial transcriptomeTranscriptional pathwaysMajor histocompatibility complex classMicroglial subpopulationsTranscriptomic signaturesEnhanced phagocytic activityMicroglial functionHistocompatibility complex classPhagocytic activityAlzheimerInterleukin (IL)-33Activation of microgliaChromatin
2021
Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
Lau S, Fu A, Ip N. Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease. Cellular And Molecular Life Sciences 2021, 78: 4703-4712. PMID: 33847763, PMCID: PMC8195901, DOI: 10.1007/s00018-021-03810-0.Peer-Reviewed Original ResearchConceptsMicroglial state transitionCytokine signaling pathwaysDanger-associated molecular patternsAlzheimer's diseaseSignaling pathwayPathogenesis of Alzheimer's diseaseAD therapeutic developmentTherapeutic developmentHyperphosphorylated tauBeta-amyloidGenetic analysisAD pathologyCytokine signalingMolecular basisAD progressionMolecular patternsMicroglial dysfunctionSignal convergenceMicroglial responseMicroglial functionStimulated microgliaFunctional stateActive statePathwayChronic activation