Rhynchophylline Administration Ameliorates Amyloid‑β Pathology and Inflammation in an Alzheimer’s Disease Transgenic Mouse Model
Fu W, Hung K, Lau S, Butt B, Yuen V, Fu G, Chan I, Ip F, Fu A, Ip N. Rhynchophylline Administration Ameliorates Amyloid‑β Pathology and Inflammation in an Alzheimer’s Disease Transgenic Mouse Model. ACS Chemical Neuroscience 2021, 12: 4249-4256. PMID: 34738783, DOI: 10.1021/acschemneuro.1c00600.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAPP/PS1 miceAD transgenic mouse modelAlzheimer's disease transgenic mouse modelTransgenic mouse modelUbiquitin-proteasome systemMolecular pathwaysAmyloid plaque burdenProteasome systemTranscriptome analysisAmyloid metabolismRegulating multiple molecular pathwaysDisease-associated pathologyMicroglial functional stateAmyloid pathologyMouse modelNeurodegenerative diseasesAPP/PS1Multiple molecular pathwaysImpaired hippocampal synaptic plasticityPathwayAlzheimerSynaptic plasticityTranscriptomeUbiquitin