Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease
Lau S, Fu A, Ip N. Cytokine signaling convergence regulates the microglial state transition in Alzheimer’s disease. Cellular And Molecular Life Sciences 2021, 78: 4703-4712. PMID: 33847763, PMCID: PMC8195901, DOI: 10.1007/s00018-021-03810-0.Peer-Reviewed Original ResearchConceptsMicroglial state transitionCytokine signaling pathwaysDanger-associated molecular patternsAlzheimer's diseaseSignaling pathwayPathogenesis of Alzheimer's diseaseAD therapeutic developmentTherapeutic developmentHyperphosphorylated tauBeta-amyloidGenetic analysisAD pathologyCytokine signalingMolecular basisAD progressionMolecular patternsMicroglial dysfunctionSignal convergenceMicroglial responseMicroglial functionStimulated microgliaFunctional stateActive statePathwayChronic activationMelanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model
Lau J, Tian M, Shen Y, Lau S, Fu W, Fu A, Ip N. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports 2021, 11: 4359. PMID: 33623128, PMCID: PMC7902646, DOI: 10.1038/s41598-021-83932-4.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAmyloid pathologyAccumulation of amyloid betaMouse model of ADAlzheimer's disease transgenic mouse modelModel of ADAPP/PS1 mouse modelAPP/PS1 mouse model of ADAPP/PS1 transgenic miceMelanocortin receptor activationAD pathogenesisAmyloid-betaMelanocortin receptorsNeurofibrillary tanglesAmyloid plaquesTranscriptome analysisMelanocortin receptor signalingHippocampus-dependent synaptic plasticityAD progressionRegulating synaptic plasticityAPP/PS1 miceSynaptic plasticityMCR activitySubtypes of reactive astrocytesFunctional role