Featured Publications
Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease
Lau S, Cao H, Fu A, Ip N. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 25800-25809. PMID: 32989152, PMCID: PMC7568283, DOI: 10.1073/pnas.2008762117.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptome analysisAngiogenic endothelial cellsAlzheimer's diseaseTranscriptome analysisEndothelial cellsCell type-specific responsesCellular targetsCell type-specific transcriptomic changesNormal controlsIncreased expression of angiogenic growth factorsType-specific responsesTherapeutic developmentAntigen presentation machineryComprehensive molecular profilingSamples of AD patientsAD brainAD pathogenesisDysregulation of endothelial cellsExpression of angiogenic growth factorsDisruption of biological processesTranscriptomic changesPrefrontal cortical samplesBiological processesCellular heterogeneityAngiogenic growth factors
2023
Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology
Lau S, Fu A, Ip N. Receptor–ligand interaction controls microglial chemotaxis and amelioration of Alzheimer's disease pathology. Journal Of Neurochemistry 2023, 166: 891-903. PMID: 37603311, DOI: 10.1111/jnc.15933.Peer-Reviewed Original ResearchConceptsDanger-associated molecular patternsMicroglial chemotaxisAD pathogenesisAlzheimer's diseaseMicroglial functionRepertoire of surface receptorsHyperphosphorylated tauAlzheimer's disease pathologyAmyloid-betaMolecular machineryMicroglial receptorsReceptor-ligand interactionsPhagocytic clearanceReceptor-ligand axisMolecular patternsSurface receptorsFunctional transitionDisease pathologyChemotaxisBrain homeostasisAberrant synaptic pruningClearance activityCritical stepsReceptorsAmyloid
2021
Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model
Lau J, Tian M, Shen Y, Lau S, Fu W, Fu A, Ip N. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports 2021, 11: 4359. PMID: 33623128, PMCID: PMC7902646, DOI: 10.1038/s41598-021-83932-4.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAmyloid pathologyAccumulation of amyloid betaMouse model of ADAlzheimer's disease transgenic mouse modelModel of ADAPP/PS1 mouse modelAPP/PS1 mouse model of ADAPP/PS1 transgenic miceMelanocortin receptor activationAD pathogenesisAmyloid-betaMelanocortin receptorsNeurofibrillary tanglesAmyloid plaquesTranscriptome analysisMelanocortin receptor signalingHippocampus-dependent synaptic plasticityAD progressionRegulating synaptic plasticityAPP/PS1 miceSynaptic plasticityMCR activitySubtypes of reactive astrocytesFunctional role