2014
Dendritic spine dysgenesis contributes to hyperreflexia after spinal cord injury
Bandaru SP, Liu S, Waxman SG, Tan AM. Dendritic spine dysgenesis contributes to hyperreflexia after spinal cord injury. Journal Of Neurophysiology 2014, 113: 1598-1615. PMID: 25505110, PMCID: PMC4346729, DOI: 10.1152/jn.00566.2014.Peer-Reviewed Original ResearchConceptsSpinal cord injuryLevel of injuryH-reflexCord injuryStretch reflexDendritic spinesSpinal cord motor systemSpine morphologyContusion spinal cord injuryExaggerated tendon jerksSpinal cord contributesRate-dependent depressionSpine profilesDendritic spine dysgenesisΑ-motor neuronsH-reflex testingTonic stretch reflexVelocity-dependent increaseAdult Sprague-DawleyM-wave responsesAbnormal dendritic spinesSpinal stretch reflexAbnormal spine morphologyDendritic spine morphologyReflex dysfunction
2013
Burn injury-induced mechanical allodynia is maintained by Rac1-regulated dendritic spine dysgenesis
Tan AM, Samad OA, Liu S, Bandaru S, Zhao P, Waxman SG. Burn injury-induced mechanical allodynia is maintained by Rac1-regulated dendritic spine dysgenesis. Experimental Neurology 2013, 248: 509-519. PMID: 23933578, DOI: 10.1016/j.expneurol.2013.07.017.Peer-Reviewed Original ResearchConceptsDendritic spine dysgenesisWDR neuronsNeuropathic painBurn injurySpine dysgenesisMechanical allodyniaInjury-induced chronic painInjury-induced mechanical allodyniaSpinal cord dorsal hornBurn-injured animalsHindpaw receptive fieldsInjury-induced painNeuropathic pain phenotypesSecond-degree burn injurySecond-degree burn modelDendritic spine morphologyDendritic spine shapeDorsal hornIntractable painMechanical painPain managementChronic painPain phenotypesElectrophysiological signsPreclinical models