Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation
Nair S, Boddupalli CS, Verma R, Liu J, Yang R, Pastores GM, Mistry PK, Dhodapkar MV. Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation. Blood 2014, 125: 1256-1271. PMID: 25499455, PMCID: PMC4335081, DOI: 10.1182/blood-2014-09-600270.Peer-Reviewed Original ResearchConceptsI NKT cellsNKT cellsB cell activationT cellsB cellsTetramer-positive T cellsType II natural killer T cellsT cell receptor usageType I NKT cellsType II NKT cellsNatural killer T cellsFollicular helper phenotypeGD mouse modelMetabolic lipid disordersKiller T cellsB cell immunityGerminal center B cellsB-cell malignanciesAntilipid antibodiesDisease activityCytokine profileChronic inflammationHelper phenotypeHumoral immunityCognate helpType II NKT-TFH Cells Against Gaucher Lipids Regulate B Cell Immunity and Inflammation
Nair S, Boddupalli C, Verma R, Liu J, Ruhua Y, Pastores G, Mistry P, Dhodapkar M. Type II NKT-TFH Cells Against Gaucher Lipids Regulate B Cell Immunity and Inflammation. Blood 2014, 124: 755. DOI: 10.1182/blood.v124.21.755.755.Peer-Reviewed Original ResearchType II NKT cellsType I NKT cellsLipid-specific T cellsI NKT cellsNKT cellsB cell immunityT cellsTFH markersAnti-lipid antibodiesΑ-GalCerGaucher diseaseB cellsCD1d tetramersTFH phenotypeCell immunityHuman PBMCsGD miceMHC-like molecule CD1dNatural killer T cellsWild-type control miceCD1d-dependent mannerDiverse NKT cellsExpansion of plasmablastsFollicular helper phenotypeAutologous B cells