2017
Natural Killer T Cells in Cancer Immunotherapy
Nair S, Dhodapkar MV. Natural Killer T Cells in Cancer Immunotherapy. Frontiers In Immunology 2017, 8: 1178. PMID: 29018445, PMCID: PMC5614937, DOI: 10.3389/fimmu.2017.01178.Peer-Reviewed Original Research
2016
ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells
Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. Journal Of Clinical Investigation 2016, 126: 3905-3916. PMID: 27617863, PMCID: PMC5096804, DOI: 10.1172/jci85329.Peer-Reviewed Original ResearchConceptsTissue-resident memory T cellsMemory T cellsT cellsTRM cellsCellular therapyAdoptive cellular therapyImmune-deficient micePotential cellular therapySP T cellsSide population cellsHuman T cellsPutative subsetsAdoptive transferDistinct gene expression profilesCell mobilizationImmune surveillanceQuiescent subsetPopulation cellsMiceTherapyQuiescent phenotypeDistinct subsetsMember 1Nuclear receptorsSignature genes
2014
Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation
Nair S, Boddupalli CS, Verma R, Liu J, Yang R, Pastores GM, Mistry PK, Dhodapkar MV. Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation. Blood 2014, 125: 1256-1271. PMID: 25499455, PMCID: PMC4335081, DOI: 10.1182/blood-2014-09-600270.Peer-Reviewed Original ResearchConceptsI NKT cellsNKT cellsB cell activationT cellsB cellsTetramer-positive T cellsType II natural killer T cellsT cell receptor usageType I NKT cellsType II NKT cellsNatural killer T cellsFollicular helper phenotypeGD mouse modelMetabolic lipid disordersKiller T cellsB cell immunityGerminal center B cellsB-cell malignanciesAntilipid antibodiesDisease activityCytokine profileChronic inflammationHelper phenotypeHumoral immunityCognate helpType II NKT-TFH Cells Against Gaucher Lipids Regulate B Cell Immunity and Inflammation
Nair S, Boddupalli C, Verma R, Liu J, Ruhua Y, Pastores G, Mistry P, Dhodapkar M. Type II NKT-TFH Cells Against Gaucher Lipids Regulate B Cell Immunity and Inflammation. Blood 2014, 124: 755. DOI: 10.1182/blood.v124.21.755.755.Peer-Reviewed Original ResearchType II NKT cellsType I NKT cellsLipid-specific T cellsI NKT cellsNKT cellsB cell immunityT cellsTFH markersAnti-lipid antibodiesΑ-GalCerGaucher diseaseB cellsCD1d tetramersTFH phenotypeCell immunityHuman PBMCsGD miceMHC-like molecule CD1dNatural killer T cellsWild-type control miceCD1d-dependent mannerDiverse NKT cellsExpansion of plasmablastsFollicular helper phenotypeAutologous B cells