2023
Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes
Vasquez-Rios G, Oh W, Lee S, Bhatraju P, Mansour S, Moledina D, Gulamali F, Siew E, Garg A, Sarder P, Chinchilli V, Kaufman J, Hsu C, Liu K, Kimmel P, Go A, Wurfel M, Himmelfarb J, Parikh C, Coca S, Nadkarni G. Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes. Clinical Journal Of The American Society Of Nephrology 2023, 18: 716-726. PMID: 36975209, PMCID: PMC10278836, DOI: 10.2215/cjn.0000000000000156.Peer-Reviewed Original ResearchConceptsSubphenotype 2Pro-brain natriuretic peptideNeutrophil gelatinase-associated lipocalinCox proportional hazards modelAKI stage 1AKI stage 2AKI stage 3Three-fold riskAcute kidney injuryTroponin T levelsGelatinase-associated lipocalinBiomarkers of inflammationKidney injury moleculeLongitudinal clinical outcomesTumor necrosis factor receptor 1Proportional hazards modelNecrosis factor receptor 1Factor receptor 1AKI subphenotypesCardiorenal eventsSepsis-AKISubphenotype 1Cardiovascular eventsKidney injuryHazard ratio
2022
Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort
Reese PP, Doshi MD, Hall IE, Besharatian B, Bromberg JS, Thiessen-Philbrook H, Jia Y, Kamoun M, Mansour SG, Akalin E, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort. American Journal Of Kidney Diseases 2022, 81: 222-231.e1. PMID: 36191727, PMCID: PMC9868058, DOI: 10.1053/j.ajkd.2022.08.011.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesBiopsy-proven acute rejectionAcute kidney injuryNeutrophil gelatinase-associated lipocalinDe novo DSAGraft failurePrimary outcomeAcute rejectionKidney recipientsKidney injurySecondary outcomesAcute Kidney Injury Network criteriaClinical acute kidney injuryNovo donor-specific antibodiesSignificant associationKidney injury molecule-1Recipient alloimmune responsesUrinary IL-18Donor-specific antibodiesFirst posttransplant yearKidney transplant recipientsInjury molecule-1Gelatinase-associated lipocalinDeceased donor kidneysFine-Gray model