2023
AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells
Wu J, Gulati S, Teague A, Kim Y, Tryggestad J, Jiang S. AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells. Stem Cells And Development 2023, 32: 131-139. PMID: 36594575, PMCID: PMC9986020, DOI: 10.1089/scd.2022.0226.Peer-Reviewed Original ResearchConceptsActivation of AMP-activated protein kinasePGC-1a expressionMitochondrial programDNA methylationCompound CMitochondrial biogenesisAMPK activationActivation of AMPKAMP-activated protein kinaseAMPK inhibitor compound CInhibition of DNA methylationRegulator of mitochondrial biogenesisRegulate mitochondrial biogenesisPGC-1aInhibitor compound CPromoter methylationIncreased mitochondrial functionRegulation of energy metabolismMitochondrial DNAEpigenetic landscapeDNA demethylationMtDNA abundanceMyogenic differentiationEpigenetic regulationProtein kinase
2017
Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis
Jiang S, Teague A, Tryggestad J, Aston C, Lyons T, Chernausek S. Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis. Placenta 2017, 57: 26-32. PMID: 28864016, PMCID: PMC5659203, DOI: 10.1016/j.placenta.2017.06.001.Peer-Reviewed Original ResearchConceptsMtDNA contentResponse to maternal diabetesMitochondrial biogenesisMitochondrial DNAPGC-1aEffects of maternal diabetesMaternal diabetesRegulator of mitochondrial biogenesisTranscription factor AImpaired mitochondrial biogenesisMitochondria transcription factor ABiogenesis pathwayMetabolic diseasesMtDNAFetal sex-specific differencesCopy numberTFAM levelsGene expressionMale offspringBiogenesisAbnormal placental functionTFAMNon-diabetic womenOffspring sexIndex of mitochondrial biogenesis