Vitamin B12 Stalls the 80S Ribosomal Complex on the Hepatitis C Internal Ribosome Entry Site
Takyar S, Gowans E, Lott W. Vitamin B12 Stalls the 80S Ribosomal Complex on the Hepatitis C Internal Ribosome Entry Site. Journal Of Molecular Biology 2002, 319: 1-8. PMID: 12051931, DOI: 10.1016/s0022-2836(02)00300-5.Peer-Reviewed Original ResearchConceptsIRES-dependent translationRibosome entry siteHepatitis C virus internal ribosome entry siteInternal ribosome entry siteEntry siteTranslation inhibitor cycloheximideS ribosomal complexCap-dependent mRNAMRNA-specificGradient centrifugation analysisSucrose gradient centrifugation analysisCompetitive binding mechanismHCV IRESRibosomal complexesTranslation inhibitorsInhibitor cycloheximideCentrifugation analysisMRNAComplex formationCycloheximideBinding mechanism