2019
In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex
Love R, Redmond S, Pombi M, Caputo B, Petrarca V, della Torre A, Consortium T, Besansky N. In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex. G3: Genes, Genomes, Genetics 2019, 9: 3249-3262. PMID: 31391198, PMCID: PMC6778791, DOI: 10.1534/g3.119.400445.Peer-Reviewed Original ResearchConceptsInversion genotypesSingle nucleotide polymorphismsInversion polymorphismTag single nucleotide polymorphismsChromosomal inversion polymorphismTag SNP genotypesAnopheles gambiae complexParacentric inversion polymorphismEnvironmental heterogeneityChromosomal rearrangementsImportant phenotypesMalaria mosquitoesSilico karyotypingNatural variationGambiae complexMosquito speciesTraditional cytogeneticsCytogenetic methodsBiallelic genotypesSignificant vectorSNP genotypesGonotrophic stagesNucleotide polymorphismsGenomeHuman malaria
2018
De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria
Redmond SN, MacInnis BM, Bopp S, Bei AK, Ndiaye D, Hartl DL, Wirth DF, Volkman SK, Neafsey DE. De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria. Molecular Biology And Evolution 2018, 35: 1678-1689. PMID: 29722884, PMCID: PMC5995194, DOI: 10.1093/molbev/msy059.Peer-Reviewed Original ResearchConceptsDe novo mutationsEvolutionary ratesSlow evolutionary rateNovo mutationsComplex life cycleSlow generation timeLow-complexity regionsGenomic regionsLarge genomesGenomic epidemiology approachReintroduction scenariosCombination of sequencingP. falciparumViral speciesMutation rateClonal lineagesGenomeMutation studiesLibrary preparationIdentical parasitesGeneration timeBacterial pathogensMalaria parasitesMutationsGenomic epidemiology
2017
Genetic diversity of the African malaria vector Anopheles gambiae
Miles A, Harding N, Bottà G, Clarkson C, Antão T, Kozak K, Schrider D, Kern A, Redmond S, Sharakhov I, Pearson R, Bergey C, Fontaine M, Donnelly M, Lawniczak M, Kwiatkowski D, Donnelly M, Ayala D, Besansky N, Burt A, Caputo B, della Torre A, Fontaine M, Godfray H, Hahn M, Kern A, Kwiatkowski D, Lawniczak M, Midega J, Neafsey D, O’Loughlin S, Pinto J, Riehle M, Sharakhov I, Vernick K, Weetman D, Wilding C, White B, Troco A, Pinto J, Diabaté A, O’Loughlin S, Burt A, Costantini C, Rohatgi K, Besansky N, Elissa N, Pinto J, Coulibaly B, Riehle M, Vernick K, Pinto J, Dinis J, Midega J, Mbogo C, Bejon P, Wilding C, Weetman D, Mawejje H, Donnelly M, Weetman D, Wilding C, Donnelly M, Stalker J, Rockett K, Drury E, Mead D, Jeffreys A, Hubbart C, Rowlands K, Isaacs A, Jyothi D, Malangone C, Vauterin P, Jeffery B, Wright I, Hart L, Kluczyński K, Cornelius V, MacInnis B, Henrichs C, Giacomantonio R, Kwiatkowski D. Genetic diversity of the African malaria vector Anopheles gambiae. Nature 2017, 552: 96-100. PMID: 29186111, PMCID: PMC6026373, DOI: 10.1038/nature24995.Peer-Reviewed Original Research
2014
Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission
Akinosoglou K, Bushell E, Ukegbu C, Schlegelmilch T, Cho J, Redmond S, Sala K, Christophides G, Vlachou D. Characterization of Plasmodium developmental transcriptomes in Anopheles gambiae midgut reveals novel regulators of malaria transmission. Cellular Microbiology 2014, 17: 254-268. PMID: 25225164, PMCID: PMC4371638, DOI: 10.1111/cmi.12363.Peer-Reviewed Original ResearchConceptsTranscriptional programsOokinete developmentRodent malaria parasite Plasmodium bergheiMalaria parasite Plasmodium bergheiDistinct transcriptional programsMosquito midgut invasionMalaria parasite populationsDevelopmental transcriptomeAnopheles gambiae mosquitoesPenetrant lossFunction phenotypesMidgut invasionHomologous recombinationGamete releasePlasmodium developmentMutant parasitesDevelopmental processesDNA microarraysGranular localizationInfection phenotypesEstablishment of infectionMosquito midgutShort polypeptidesParasite populationsParasite development
2010
SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes
Neafsey D, Lawniczak M, Park D, Redmond S, Coulibaly M, Traoré S, Sagnon N, Costantini C, Johnson C, Wiegand R, Collins F, Lander E, Wirth D, Kafatos F, Besansky N, Christophides G, Muskavitch M. SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes. Science 2010, 330: 514-517. PMID: 20966254, PMCID: PMC4811326, DOI: 10.1126/science.1193036.Peer-Reviewed Original ResearchConceptsGenomic differentiationGenome-wide monitoringGreater genetic divergenceVector mosquito populationsMalaria vector mosquitoesAfrican malaria vector mosquitoesReproductive isolationBehavioral diversificationGenetic divergenceGenomic regionsNatural selectionPopulation structurePolymorphic inversionsSelective eventsSNP genotypingVector control effortsMosquito populationsVector mosquitoesDifferentiationComplex showDivergenceMosquitoesCentromeresGenomeSpecies