2020
Linked-read sequencing identifies abundant microinversions and introgression in the arboviral vector Aedes aegypti
Redmond S, Sharma A, Sharakhov I, Tu Z, Sharakhova M, Neafsey D. Linked-read sequencing identifies abundant microinversions and introgression in the arboviral vector Aedes aegypti. BMC Biology 2020, 18: 26. PMID: 32164699, PMCID: PMC7068900, DOI: 10.1186/s12915-020-0757-y.Peer-Reviewed Original ResearchConceptsChromosomal inversionsFuture population genetic studiesRelated sister speciesPolytene chromosome analysisArboviral vector Aedes aegyptiLinked-read sequencingPopulation genetic studiesChromosome banding patternsHost-feeding preferencesAedes aegyptiPhenotypic divergenceSister speciesSecondary contactChromosomal diversityDeep Illumina sequencingDipteran insectsRepetitive genomesIllumina sequencingFeeding preferencesGenomic rearrangementsHost preferenceSequencing dataVector Aedes aegyptiGenetic studiesSubspecies
2013
The zebrafish reference genome sequence and its relationship to the human genome
Howe K, Clark M, Torroja C, Torrance J, Berthelot C, Muffato M, Collins J, Humphray S, McLaren K, Matthews L, McLaren S, Sealy I, Caccamo M, Churcher C, Scott C, Barrett J, Koch R, Rauch G, White S, Chow W, Kilian B, Quintais L, Guerra-Assunção J, Zhou Y, Gu Y, Yen J, Vogel J, Eyre T, Redmond S, Banerjee R, Chi J, Fu B, Langley E, Maguire S, Laird G, Lloyd D, Kenyon E, Donaldson S, Sehra H, Almeida-King J, Loveland J, Trevanion S, Jones M, Quail M, Willey D, Hunt A, Burton J, Sims S, McLay K, Plumb B, Davis J, Clee C, Oliver K, Clark R, Riddle C, Elliott D, Threadgold G, Harden G, Ware D, Begum S, Mortimore B, Kerry G, Heath P, Phillimore B, Tracey A, Corby N, Dunn M, Johnson C, Wood J, Clark S, Pelan S, Griffiths G, Smith M, Glithero R, Howden P, Barker N, Lloyd C, Stevens C, Harley J, Holt K, Panagiotidis G, Lovell J, Beasley H, Henderson C, Gordon D, Auger K, Wright D, Collins J, Raisen C, Dyer L, Leung K, Robertson L, Ambridge K, Leongamornlert D, McGuire S, Gilderthorp R, Griffiths C, Manthravadi D, Nichol S, Barker G, Whitehead S, Kay M, Brown J, Murnane C, Gray E, Humphries M, Sycamore N, Barker D, Saunders D, Wallis J, Babbage A, Hammond S, Mashreghi-Mohammadi M, Barr L, Martin S, Wray P, Ellington A, Matthews N, Ellwood M, Woodmansey R, Clark G, Cooper J, Tromans A, Grafham D, Skuce C, Pandian R, Andrews R, Harrison E, Kimberley A, Garnett J, Fosker N, Hall R, Garner P, Kelly D, Bird C, Palmer S, Gehring I, Berger A, Dooley C, Ersan-Ürün Z, Eser C, Geiger H, Geisler M, Karotki L, Kirn A, Konantz J, Konantz M, Oberländer M, Rudolph-Geiger S, Teucke M, Lanz C, Raddatz G, Osoegawa K, Zhu B, Rapp A, Widaa S, Langford C, Yang F, Schuster S, Carter N, Harrow J, Ning Z, Herrero J, Searle S, Enright A, Geisler R, Plasterk R, Lee C, Westerfield M, de Jong P, Zon L, Postlethwait J, Nüsslein-Volhard C, Hubbard T, Crollius H, Rogers J, Stemple D. The zebrafish reference genome sequence and its relationship to the human genome. Nature 2013, 496: 498-503. PMID: 23594743, PMCID: PMC3703927, DOI: 10.1038/nature12111.Peer-Reviewed Original ResearchConceptsHigh-quality sequence assembliesHuman protein-coding genesProtein-coding genesReference genome sequenceKey genomic featuresHuman reference genomeZebrafish genomeZebrafish orthologueReference genomeGenome sequenceHuman genomeSequence assemblyGenomic featuresLarge genesGenomeGenesOrthologuesVertebratesSequenceAssembly
2006
Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome
Subramaniam C, Veazey P, Redmond S, Hayes-Sinclair J, Chambers E, Carrington M, Gull K, Matthews K, Horn D, Field M. Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome. MSphere 2006, 5: 1539-1549. PMID: 16963636, PMCID: PMC1563588, DOI: 10.1128/ec.00141-06.Peer-Reviewed Original ResearchConceptsOpen reading frameRNA interferenceGene functionChromosome IT. bruceiDrug targetsChromosome-wide analysisBloodstream form parasitesCell cycle progressionPotential drug targetsNew drug targetsTrypanosome genomeGrowth defectOrder KinetoplastidaGenome sequenceAffected cell growthI geneParasite biologyReading frameGene productsTrypanosoma bruceiBasic biologyParasitic organismsAfrican trypanosomesCycle progression