2019
In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex
Love R, Redmond S, Pombi M, Caputo B, Petrarca V, della Torre A, Consortium T, Besansky N. In Silico Karyotyping of Chromosomally Polymorphic Malaria Mosquitoes in the Anopheles gambiae Complex. G3: Genes, Genomes, Genetics 2019, 9: 3249-3262. PMID: 31391198, PMCID: PMC6778791, DOI: 10.1534/g3.119.400445.Peer-Reviewed Original ResearchConceptsInversion genotypesSingle nucleotide polymorphismsInversion polymorphismTag single nucleotide polymorphismsChromosomal inversion polymorphismTag SNP genotypesAnopheles gambiae complexParacentric inversion polymorphismEnvironmental heterogeneityChromosomal rearrangementsImportant phenotypesMalaria mosquitoesSilico karyotypingNatural variationGambiae complexMosquito speciesTraditional cytogeneticsCytogenetic methodsBiallelic genotypesSignificant vectorSNP genotypesGonotrophic stagesNucleotide polymorphismsGenomeHuman malaria
2017
Genetic diversity of the African malaria vector Anopheles gambiae
Miles A, Harding N, Bottà G, Clarkson C, Antão T, Kozak K, Schrider D, Kern A, Redmond S, Sharakhov I, Pearson R, Bergey C, Fontaine M, Donnelly M, Lawniczak M, Kwiatkowski D, Donnelly M, Ayala D, Besansky N, Burt A, Caputo B, della Torre A, Fontaine M, Godfray H, Hahn M, Kern A, Kwiatkowski D, Lawniczak M, Midega J, Neafsey D, O’Loughlin S, Pinto J, Riehle M, Sharakhov I, Vernick K, Weetman D, Wilding C, White B, Troco A, Pinto J, Diabaté A, O’Loughlin S, Burt A, Costantini C, Rohatgi K, Besansky N, Elissa N, Pinto J, Coulibaly B, Riehle M, Vernick K, Pinto J, Dinis J, Midega J, Mbogo C, Bejon P, Wilding C, Weetman D, Mawejje H, Donnelly M, Weetman D, Wilding C, Donnelly M, Stalker J, Rockett K, Drury E, Mead D, Jeffreys A, Hubbart C, Rowlands K, Isaacs A, Jyothi D, Malangone C, Vauterin P, Jeffery B, Wright I, Hart L, Kluczyński K, Cornelius V, MacInnis B, Henrichs C, Giacomantonio R, Kwiatkowski D. Genetic diversity of the African malaria vector Anopheles gambiae. Nature 2017, 552: 96-100. PMID: 29186111, PMCID: PMC6026373, DOI: 10.1038/nature24995.Peer-Reviewed Original Research
2015
Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae
Redmond S, Eiglmeier K, Mitri C, Markianos K, Guelbeogo W, Gneme A, Isaacs A, Coulibaly B, Brito-Fravallo E, Maslen G, Mead D, Niare O, Traore S, Sagnon N, Kwiatkowski D, Riehle M, Vernick K. Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae. BMC Genomics 2015, 16: 779. PMID: 26462916, PMCID: PMC4603968, DOI: 10.1186/s12864-015-2009-z.Peer-Reviewed Original ResearchConceptsGenetic mappingFounder coloniesHigh nucleotide diversityNon-model genomesLow linkage disequilibriumPhenotype-genotype mappingPopulation stratificationParasite infection levelsHuman malaria parasiteGenotyping of SNPsNucleotide diversityPooled sequencesAssociation mappingGenomic lociLinkage mappingPlasmodium falciparumSignificant SNPsMosquito systemMarker densityDNA poolsAnopheles gambiaeNatural variationIndividual mosquitoesLinkage disequilibriumSequencing identifies
2010
SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes
Neafsey D, Lawniczak M, Park D, Redmond S, Coulibaly M, Traoré S, Sagnon N, Costantini C, Johnson C, Wiegand R, Collins F, Lander E, Wirth D, Kafatos F, Besansky N, Christophides G, Muskavitch M. SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector Mosquitoes. Science 2010, 330: 514-517. PMID: 20966254, PMCID: PMC4811326, DOI: 10.1126/science.1193036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnophelesFemaleGene FlowGenes, InsectGenotypeInsect VectorsMalariaPolymorphism, Single NucleotideConceptsGenomic differentiationGenome-wide monitoringGreater genetic divergenceVector mosquito populationsMalaria vector mosquitoesAfrican malaria vector mosquitoesReproductive isolationBehavioral diversificationGenetic divergenceGenomic regionsNatural selectionPopulation structurePolymorphic inversionsSelective eventsSNP genotypingVector control effortsMosquito populationsVector mosquitoesDifferentiationComplex showDivergenceMosquitoesCentromeresGenomeSpeciesWidespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences
Lawniczak M, Emrich S, Holloway A, Regier A, Olson M, White B, Redmond S, Fulton L, Appelbaum E, Godfrey J, Farmer C, Chinwalla A, Yang S, Minx P, Nelson J, Kyung K, Walenz B, Garcia-Hernandez E, Aguiar M, Viswanathan L, Rogers Y, Strausberg R, Saski C, Lawson D, Collins F, Kafatos F, Christophides G, Clifton S, Kirkness E, Besansky N. Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences. Science 2010, 330: 512-514. PMID: 20966253, PMCID: PMC3674514, DOI: 10.1126/science.1195755.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnophelesEvolution, MolecularFemaleGene FlowGenetic SpeciationGenome, InsectMaleModels, GeneticPolymorphism, Single NucleotideConceptsSpeciation processGenome sequencePrevious genome-wide scanHeterogeneous genomic divergenceAnopheles gambiae speciesGenome-wide scanUnknown genetic mechanismsWhole genome sequencesGene flowGenomic divergenceLarval ecologyGambiae speciesAnopheles gambiae sensu strictoPericentromeric regionGambiae sensu strictoGenetic mechanismsWidespread divergenceSensu strictoReproductive behaviorMajor vectorDivergenceSpeciationSequenceAppreciable levelsMolecular forms