2015
Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae
Redmond S, Eiglmeier K, Mitri C, Markianos K, Guelbeogo W, Gneme A, Isaacs A, Coulibaly B, Brito-Fravallo E, Maslen G, Mead D, Niare O, Traore S, Sagnon N, Kwiatkowski D, Riehle M, Vernick K. Association mapping by pooled sequencing identifies TOLL 11 as a protective factor against Plasmodium falciparum in Anopheles gambiae. BMC Genomics 2015, 16: 779. PMID: 26462916, PMCID: PMC4603968, DOI: 10.1186/s12864-015-2009-z.Peer-Reviewed Original ResearchConceptsGenetic mappingFounder coloniesHigh nucleotide diversityNon-model genomesLow linkage disequilibriumPhenotype-genotype mappingPopulation stratificationParasite infection levelsHuman malaria parasiteGenotyping of SNPsNucleotide diversityPooled sequencesAssociation mappingGenomic lociLinkage mappingPlasmodium falciparumSignificant SNPsMosquito systemMarker densityDNA poolsAnopheles gambiaeNatural variationIndividual mosquitoesLinkage disequilibriumSequencing identifies
2011
The Chado Natural Diversity module: a new generic database schema for large-scale phenotyping and genotyping data
Jung S, Menda N, Redmond S, Buels R, Friesen M, Bendana Y, Sanderson L, Lapp H, Lee T, MacCallum B, Bett K, Cain S, Clements D, Mueller L, Main D. The Chado Natural Diversity module: a new generic database schema for large-scale phenotyping and genotyping data. Database 2011, 2011: bar051. PMID: 22120662, PMCID: PMC3225077, DOI: 10.1093/database/bar051.Peer-Reviewed Original Research
2006
Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome
Subramaniam C, Veazey P, Redmond S, Hayes-Sinclair J, Chambers E, Carrington M, Gull K, Matthews K, Horn D, Field M. Chromosome-Wide Analysis of Gene Function by RNA Interference in the African Trypanosome. MSphere 2006, 5: 1539-1549. PMID: 16963636, PMCID: PMC1563588, DOI: 10.1128/ec.00141-06.Peer-Reviewed Original ResearchConceptsOpen reading frameRNA interferenceGene functionChromosome IT. bruceiDrug targetsChromosome-wide analysisBloodstream form parasitesCell cycle progressionPotential drug targetsNew drug targetsTrypanosome genomeGrowth defectOrder KinetoplastidaGenome sequenceAffected cell growthI geneParasite biologyReading frameGene productsTrypanosoma bruceiBasic biologyParasitic organismsAfrican trypanosomesCycle progression