2018
Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility
Demas A, Sharma A, Wong W, Early A, Redmond S, Bopp S, Neafsey D, Volkman S, Hartl D, Wirth D. Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 12799-12804. PMID: 30420498, PMCID: PMC6294886, DOI: 10.1073/pnas.1812317115.Peer-Reviewed Original ResearchConceptsCRISPR/Cas9-mediated gene editingDomain protein familyWhole genome sequence analysisProtein familySecond geneFunctional validationMutant formsDifferent genesMolecular mechanismsParental linesSequence analysisType of resistanceGene editingAfrican parasitesArtemisinin susceptibilityMechanisms of resistanceGenesGenetic determinantsParental parasitesMutationsSurvival assaysIndependent selectionParasite clonesProteinActive form
2012
Transcriptome of the adult female malaria mosquito vector Anopheles albimanus
Martínez-Barnetche J, Gómez-Barreto R, Ovilla-Muñoz M, Téllez-Sosa J, López D, Dinglasan R, Mohien C, MacCallum R, Redmond S, Gibbons J, Rokas A, Machado C, Cazares-Raga F, González-Cerón L, Hernández-Martínez S, López M. Transcriptome of the adult female malaria mosquito vector Anopheles albimanus. BMC Genomics 2012, 13: 207. PMID: 22646700, PMCID: PMC3442982, DOI: 10.1186/1471-2164-13-207.Peer-Reviewed Original ResearchConceptsMalaria vectorsProtein-coding transcriptsAvailable genomic informationPlasmodium-mosquito interactionsHigh-quality assemblyImportant malaria vectorAnopheles albimanusFemale transcriptomesPutative orthologsDivergence timesPlasmodium lifecycleEukaryotic genomesTranscriptome projectsEvolutionary biologyInterPro annotationProtein familyMosquito biologyInsect vectorsGenomic informationNeotropical vectorsCDNA libraryIllumina sequencesAnopheline mosquito vectorsGenus AnophelesFat body