Differential Release of Plasminogen Activator Inhibitors (PAIs) During Dual Perfusion of Human Placenta: Implications in Preeclampsia
Guller S, Ma Y, Malek A, Di Santo S, Schneider H. Differential Release of Plasminogen Activator Inhibitors (PAIs) During Dual Perfusion of Human Placenta: Implications in Preeclampsia. Placenta 2006, 28: 278-285. PMID: 16820203, DOI: 10.1016/j.placenta.2006.05.005.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionPAI-1 levelsPlasminogen activator inhibitorTotal PAI-1 levelsMaternal perfusateDual perfusionTime-dependent increaseReactive oxygen speciesRelease of PAIActivator inhibitorIntervillous fibrin depositionActive PAI-1 levelsSignificant time-dependent increasePAI-2 levelsPAI-1 releaseHuman term placentaPlacental tissue extractsAberrant fibrinolysisPlacental infarctionMaternal serumFibrin depositionGrowth restrictionIntervillous spacePreeclampsiaTerm placenta