2022
Hyperammonemia syndrome in immunosuppressed individuals
Roberts SC, Malik W, Ison MG. Hyperammonemia syndrome in immunosuppressed individuals. Current Opinion In Infectious Diseases 2022, 35: 262-268. PMID: 35665721, PMCID: PMC9179651, DOI: 10.1097/qco.0000000000000828.Peer-Reviewed Original ResearchConceptsLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsImmunosuppressed individualsSolid organ transplant populationLung transplant donorsOrgan transplant populationPeri-transplant periodAppropriate antimicrobial therapyUrease-producing organismsHigh mortality rateTransplant populationTransplant donorsClinical manifestationsFatal conditionAntimicrobial therapySurveillance studyMortality rateSystemic infectionSyndromeDonor colonizationAntibiotic resistanceRapid diagnosticsRecipientsAn outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era
Roberts SC, Palacios C, Grubaugh ND, Alpert T, Ott IM, Breban MI, Initiative Y, Martinello RA, Smith C, Davis MW, Mcmanus D, Tirmizi S, Topal JE, Azar MM, Malinis M. An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era. Transplant Infectious Disease 2022, 24: e13782. PMID: 34969164, DOI: 10.1111/tid.13782.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Infection prevention practicesSARS-CoV-2 outbreakTransplant unitCOVID-19-associated morbiditySolid organ transplant recipientsSARS-CoV-2 vaccinationPrevention practicesHospital day 18Potential index casesOrgan transplant recipientsInfection prevention behaviorsMonoclonal antibody therapyCOVID-19SARS-CoV-2 clustersHospital staff membersWhole-genome sequencingAsymptomatic patientsTransplant recipientsPositive patientsAtypical presentationImmunocompromised patientsAntibody therapyVaccination eraDisease progression
2020
1164. Epidemiology of Cryptococcal Infections in Non-HIV Patients: A 20-year Single Center Experience
Kumar R, Nam H, Roberts S, Penugonda S, Angarone M, Stosor V. 1164. Epidemiology of Cryptococcal Infections in Non-HIV Patients: A 20-year Single Center Experience. Open Forum Infectious Diseases 2020, 7: s608-s608. PMCID: PMC7776216, DOI: 10.1093/ofid/ofaa439.1350.Peer-Reviewed Original ResearchCryptococcal antigenRisk factorsCerebrospinal fluidSingle-center retrospective cohort studyCenter retrospective cohort studySolid organ transplant recipientsCommon predisposing conditionsNon-HIV patientsPositive cryptococcal antigenPositive culture dataRetrospective cohort studyChronic kidney diseaseOrgan transplant recipientsSingle-center experienceSolid organ transplantsTime of diagnosisUse of immunosuppressionNorthwestern Memorial HospitalCentral nervous systemSite of infectionHospital mortalityCryptococcal infectionTransplant recipientsCohort studyPredisposing condition540. Prolonged Viral Shedding of SARS-CoV-2 In Solid Organ Transplant Recipients
Nam H, Roberts S, Tanna S, Ison M. 540. Prolonged Viral Shedding of SARS-CoV-2 In Solid Organ Transplant Recipients. Open Forum Infectious Diseases 2020, 7: s337-s337. PMCID: PMC7777463, DOI: 10.1093/ofid/ofaa439.734.Peer-Reviewed Original ResearchSolid organ transplant recipientsOrgan transplant recipientsViral sheddingSevere diseaseTransplant recipientsSARS-CoV-2SOT recipientsMedian durationPositive SARS-CoV-2 PCR testPositive SARS-CoV-2 RTSARS-CoV-2 PCR resultSARS-CoV-2 PCR testSARS-CoV-2 PCR positivitySARS-CoV-2 infectionSARS-CoV-2 RTKidney transplant recipientsMajority of patientsConclusion COVID-19COVID-19African American/BlackKidney recipientsSOT patientsMedian ageModerate diseaseOverall mortalityImpact of Screening and Treatment of Ureaplasma species on Hyperammonemia Syndrome in Lung Transplant Recipients: A Single Center Experience
Roberts SC, Bharat A, Kurihara C, Tomic R, Ison MG. Impact of Screening and Treatment of Ureaplasma species on Hyperammonemia Syndrome in Lung Transplant Recipients: A Single Center Experience. Clinical Infectious Diseases 2020, 73: e2531-e2537. PMID: 33068392, PMCID: PMC8563172, DOI: 10.1093/cid/ciaa1570.Peer-Reviewed Original ResearchConceptsLung transplant recipientsLung transplantUreaplasma sppHyperammonemia syndromePolymerase chain reactionTransplant recipientsUreaplasma speciesSingle-center experienceBronchoalveolar lavage cultureRecipients of organsNegative screening testImpact of screeningFuture confirmatory studiesEmpiric therapyNew onsetLung donorsCenter experienceDonor testingUrine cultureLavage cultureMental statusAntimicrobial therapyTransplantPatientsScreening testInfection with Ureaplasma spp in Lung Transplant Recipients is Donor-Derived
Roberts S, Bharat A, Kurihara C, Ison M. Infection with Ureaplasma spp in Lung Transplant Recipients is Donor-Derived. The Journal Of Heart And Lung Transplantation 2020, 39: s47. DOI: 10.1016/j.healun.2020.01.1220.Peer-Reviewed Original ResearchLung transplant recipientsUreaplasma sppHyperammonemia syndromeTransplant recipientsPositive donorsBronchoalveolar lavageMethods Consecutive patientsNorthwestern Memorial HospitalTime of implantationMicrobial confirmationConsecutive patientsDonor testingConclusions InfectionMemorial HospitalRisk factorsAntimicrobial therapyLTxRsResults SixtyMurine modelNegative testingPatientsActive malesPurpose Recent studiesInfectionHuman subjects
2019
1771. Donor-derived Ureaplasma Infection Increases Mortality in Lung Transplant Recipients
Roberts S, Bharat A, Kurihara C, Bhorade S, Ison M. 1771. Donor-derived Ureaplasma Infection Increases Mortality in Lung Transplant Recipients. Open Forum Infectious Diseases 2019, 6: s653-s653. PMCID: PMC6809047, DOI: 10.1093/ofid/ofz360.1634.Peer-Reviewed Original ResearchDonor-derived infectionTime of LTxLung transplant recipientsHyperammonemia syndromeUreaplasma sppTransplant recipientsDonor screeningPCR testingPre-transplant screeningRetrospective cohort studyRenal replacement therapyBronchoalveolar lavage cultureNegative screening testNorthwestern Memorial HospitalSPSS Statistics version 25.0Donor transmissionEmpiric therapyCohort studyRetrospective cohortDonor testingUrine cultureLavage cultureReplacement therapyMemorial HospitalMental status