2020
Implantable Cardioverter Defibrillator Utilization and Mortality Among Patients ≥65 Years of Age With a Low Ejection Fraction After Coronary Revascularization
Goldstein S, Li S, Lu D, Matsouaka R, Rymer J, Fonarow G, de Lemos J, Peterson E, Pokorney S, Wang T, Al-Khatib S. Implantable Cardioverter Defibrillator Utilization and Mortality Among Patients ≥65 Years of Age With a Low Ejection Fraction After Coronary Revascularization. The American Journal Of Cardiology 2020, 138: 26-32. PMID: 33068540, DOI: 10.1016/j.amjcard.2020.09.056.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAge FactorsAgedAged, 80 and overCardiologyCoronary Artery BypassDeath, Sudden, CardiacDefibrillators, ImplantableFemaleHeart FailureHumansMaleMedicareMortalityMyocardial InfarctionMyocardial RevascularizationPatient ReadmissionPercutaneous Coronary InterventionProportional Hazards ModelsSex FactorsStroke VolumeTachycardia, VentricularUnited StatesVentricular FibrillationConceptsImplantable cardioverter-defibrillator implantationImplantable cardioverter-defibrillatorIn-hospital ventricular arrhythmiasLow ejection fractionAssociated with ICD implantationEjection fractionVentricular arrhythmiasICD implantationCoronary revascularizationCABG-treated patientsPCI-treated patientsAssociated with lower mortalityCardiology follow-upIn-hospital revascularizationAll-cause mortalityAssociated with higher likelihoodICD utilizationHeart failure readmissionHeart failureYear of revascularizationCardioverter-defibrillatorRevascularization strategyMedicare claimsRevascularizationPatientsCauses of Death and Cardiovascular Comorbidities in Adults With Congenital Heart Disease
Goldstein S, D’Ottavio A, Spears T, Chiswell K, Hartman R, Krasuski R, Kemper A, Meyer R, Hoffman T, Walsh M, Sang C, Paolillo J, Li J. Causes of Death and Cardiovascular Comorbidities in Adults With Congenital Heart Disease. Journal Of The American Heart Association 2020, 9: e016400. PMID: 32654582, PMCID: PMC7660712, DOI: 10.1161/jaha.119.016400.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCause of DeathCohort StudiesComorbidityFemaleHeart Defects, CongenitalHumansMaleNorth CarolinaRisk FactorsConceptsCongenital heart diseaseSevere congenital heart diseaseMedian ageNonsevere CHDPresence of cardiovascular comorbiditiesHeart diseaseCardiovascular risk factorsNon-CHD causesIschemic heart diseaseElectronic medical record dataDeath certificate dataCause of deathNonsevere diseaseContemporary cohortValvular lesionsCardiovascular comorbidityCardiovascular comorbiditiesResults PatientsCardiovascular deathMedical record dataRisk factorsSevere groupLesion severityPatientsCertificate data
2019
Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial)
Goldstein S, Green J, Huber K, Wojdyla D, Lopes R, Alexander J, Vinereanu D, Wallentin L, Granger C, Al-Khatib S. Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial). The American Journal Of Cardiology 2019, 124: 1406-1412. PMID: 31474328, PMCID: PMC7194994, DOI: 10.1016/j.amjcard.2019.07.046.Peer-Reviewed Original ResearchConceptsThyroid disease historyThyroid diseaseAtrial fibrillationDisease historyThromboembolic eventsClinical outcomesOutcomes of atrial fibrillationHistory of thyroid diseaseBaseline characteristics of patientsCox modelBenefits of apixabanOther Thromboembolic EventsCharacteristics of patientsEffects of anticoagulantsAdjusted hazard ratiosBaseline characteristicsCompare outcomesHazard ratioThyroidApixabanPatientsRandomized treatmentWarfarinHypothyroidismDisease
2018
Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes
Goldstein S, Mentz R, Hellkamp A, Randolph T, Fonarow G, Hernandez A, Yancy C, Al‐Khatib S. Timing of cardiac resynchronization therapy device implantation in heart failure patients and its association with outcomes. Clinical Cardiology 2018, 42: 256-263. PMID: 30548280, PMCID: PMC6386168, DOI: 10.1002/clc.23135.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapy implantationCardiac resynchronization therapyHF re-hospitalizationHeart failureRe-hospitalizationHF hospitalizationCardiac resynchronization therapy device implantationOutcome of all-cause mortalityTime of CRT implantationAssociated with clinical outcomesAssociated with similar benefitsAll-cause mortalityAssociated with lower ratesHeart failure patientsCRT implantationResynchronization therapyClinical outcomesHF patientsDevice implantationFailure patientsCenters for MedicarePatientsDelayed implantationReduce mortalityMedicaid Services data
2016
Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non–ST-Segment–Elevation Acute Coronary Syndromes Clinical Trials
Kragholm K, Goldstein S, Yang Q, Lopes R, Schulte P, Bernacki G, White H, Mahaffey K, Giugliano R, Armstrong P, Harrington R, Tricoci P, Van de Werf F, Alexander J, Alexander K, Newby L. Trends in Enrollment, Clinical Characteristics, Treatment, and Outcomes According to Age in Non–ST-Segment–Elevation Acute Coronary Syndromes Clinical Trials. Circulation 2016, 133: 1560-1573. PMID: 26957532, PMCID: PMC4856566, DOI: 10.1161/circulationaha.115.017299.Peer-Reviewed Original ResearchConceptsIncrease evidence-based careEvidence-based careClinical characteristicsClinical trialsAcute coronary syndrome trialsTranslation of clinical trialNon-ST segment elevation acute coronary syndromeNon-ST segment elevationPhase III clinical trialsPost-myocardial infarction mortalityIII clinical trialsClinical trial enrollmentInfarction mortalityAcute coronary syndromeClinical trial populationsAge strataGeneral populationTrial enrollmentIn-hospitalCoronary syndromeOlder patientsIncreased comorbiditiesTrial backgroundTrial populationEnrollment