A Randomized, Double-Blind, Placebo-Controlled Trial of Low-Dose Sertraline in Young Children With Fragile X Syndrome
Greiss Hess L, Fitzpatrick S, Nguyen D, Chen Y, Gaul K, Schneider A, Lemons Chitwood K, Eldeeb M, Polussa J, Hessl D, Rivera S, Hagerman R. A Randomized, Double-Blind, Placebo-Controlled Trial of Low-Dose Sertraline in Young Children With Fragile X Syndrome. Journal Of Developmental And Behavioral Pediatrics 2016, 37: 619-628. PMID: 27560971, PMCID: PMC5039060, DOI: 10.1097/dbp.0000000000000334.Peer-Reviewed Original ResearchConceptsLow-dose sertralineEL developmentFragile X syndromeYoung childrenSensory Processing Measure–PreschoolVisual perceptual abilitiesAutism spectrum disorderSocial participationLong-term side effectsPerceptual abilitiesMullen ScalesLanguage developmentSpectrum disorderX syndromeAge equivalentsSide effectsSertraline armClinical Global Impression Scale-ImprovementMSELEarly childhoodSelective serotonin reuptake inhibitorsGlobal clinical improvementChildrenPlacebo-controlled trialSerious adverse events