2017
Challenges in Conducting Clinical Trials for Pharmacotherapies in Fragile X Syndrome: Lessons Learned
Harkins C, Dominick K, Wink L, Pedapati E, Shaffer R, Fitzpatrick S, Davenport M, Sweeney J, Erickson C. Challenges in Conducting Clinical Trials for Pharmacotherapies in Fragile X Syndrome: Lessons Learned. Pharmaceutical Medicine 2017, 31: 235-244. DOI: 10.1007/s40290-017-0199-1.Peer-Reviewed Original ResearchAutism spectrum disorderFragile X syndromeBehavioral outcome measuresClinician-reported instrumentsUse of parentsBehavioral measuresEye gazeSpectrum disorderNeuroscientific advancesReport instrumentX syndromeTreatment developmentCommon single gene causeBrain functionRater biasBehavioral heterogeneityIntellectual disabilityPharmacotherapy trialsOutcome measuresPotential explanationTreatment-associated changesQuantitative measuresMeasuresDisordersFuture success
2016
Premutation-Associated Disorders in Childhood and Adulthood
Hagerman R, Wheeler A, Fitzpatrick S, Hunter J. Premutation-Associated Disorders in Childhood and Adulthood. 2016, 241-262. DOI: 10.1007/978-3-319-33898-9_12.ChaptersCentral nervous system findingsHealth care providersClinical symptomsSignificant clinical involvementSystem findingsLifestyle changesCare providersPsychiatric problemsPsychiatric aspectsClinical involvementMost childrenPremutation involvementPremutation-associated disordersMost adultsPremutation carriersDisordersInvolvementRNA toxicityPremutationSymptomsAggression in autism spectrum disorder: presentation and treatment options
Fitzpatrick S, Srivorakiat L, Wink L, Pedapati E, Erickson C. Aggression in autism spectrum disorder: presentation and treatment options. Neuropsychiatric Disease And Treatment 2016, Volume 12: 1525-1538. PMID: 27382295, PMCID: PMC4922773, DOI: 10.2147/ndt.s84585.Peer-Reviewed Original ResearchAutism spectrum disorderSpectrum disorderFunctional communication trainingASD diagnosisFunctional behavioral assessmentSocial communicationNegative outcomesSocial interactionSocial supportDevelopmental disabilitiesPersistent difficultiesBehavioral assessmentCommunication trainingAggressionNeurodevelopmental disordersAggressive behaviorRepetitive patternsDisordersReinforcement strategiesIndividualsStress levelsQuality of lifeAggression ratesCaregiversSecond-generation antipsychotics