2007
Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome
Legro R, Barnhart H, Schlaff W, Carr B, Diamond M, Carson S, Steinkampf M, Coutifaris C, McGovern P, Cataldo N, Gosman G, Nestler J, Giudice L, Leppert P, Myers E. Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2007, 62: 386-388. DOI: 10.1097/01.ogx.0000265909.61668.01.Peer-Reviewed Original ResearchPolycystic ovary syndromeExtended-release metforminMetformin groupLive birthsTreatment groupsClomiphene citrateOvary syndromeInfertile womenPregnancy lossSex hormone-binding globulin levelsAbstract Polycystic ovary syndromeHormone-binding globulin levelsFirst trimester pregnancy lossClomiphene-treated patientsDose of clomipheneMetformin-treated womenPlacebo-controlled trialSerious adverse eventsFirst-line treatmentFree androgen indexLive birth rateGastrointestinal side effectsBody mass indexEarly pregnancy lossSingle drug group
1998
Lack of Association Between Antiphospholipid Antibodies and First-Trimester Spontaneous Abortion: Prospective Study of Pregnancies Detected Within 21 Days of Conception 11Supported by grants and contracts from the National Institute of Child Health and Human Development, National Institutes of Health.
Simpson J, Carson S, Chesney C, Conley M, Metzger B, Aarons J, Holmes L, Jovanovic-Peterson L, Knopp R, Mills J. Lack of Association Between Antiphospholipid Antibodies and First-Trimester Spontaneous Abortion: Prospective Study of Pregnancies Detected Within 21 Days of Conception 11Supported by grants and contracts from the National Institute of Child Health and Human Development, National Institutes of Health. Fertility And Sterility 1998, 69: 814-820. PMID: 9591485, DOI: 10.1016/s0015-0282(98)00054-5.Peer-Reviewed Original ResearchConceptsAntiphospholipid antibodiesAnticardiolipin antibodiesPregnancy lossProspective studyFirst trimester pregnancy lossEnzyme immunoassayFirst-trimester spontaneous abortionsFirst trimester lossNational InstituteLack of associationDay of conceptionFetal deathRetrospective studySpontaneous abortionLive birthsMAIN OUTCOMEChild healthSuch antibodiesBlood samplesPregnancyMulticenter universityAntibodiesSerumWomenSelection bias
1996
Prospective study showing that antisperm antibodies are not associated with pregnancy losses**Supported by a contract with the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Simpson J, Carson S, Mills J, Conley M, Aarons J, Holmes L, Jovanovic-Peterson L, Knopp R, Metzger B. Prospective study showing that antisperm antibodies are not associated with pregnancy losses**Supported by a contract with the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Fertility And Sterility 1996, 66: 36-42. PMID: 8752608, DOI: 10.1016/s0015-0282(16)58384-8.Peer-Reviewed Original ResearchConceptsIgM antisperm antibodiesAntisperm antibodiesPregnancy lossIgA antisperm antibodiesNondiabetic womenPregnancy outcomesPositive findingsFirst trimester pregnancy lossTrimester pregnancy lossFirst-trimester serumIndirect immunobead testNational InstituteOnly positive findingDay of conceptionMaternal serumClinical statusProspective studyImmunobead testLiveborn infantsProspective dataChild healthPositive testIgM bindingRegional bindingLocation of antibody