Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral AngiographyLiverMagnetic Resonance SpectroscopyMiceRatsSpleenTissue DistributionConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiographyMethylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST
Zakaria ABM, Huang Y, Coman D, Mishra SK, Mihailovic JM, Maritim S, Rojas‐Quijano F, Jurek P, Kiefer GE, Hyder F. Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST. NMR In Biomedicine 2022, 35: e4687. PMID: 34970801, DOI: 10.1002/nbm.4687.Peer-Reviewed Original ResearchAmidesBiosensing TechniquesChelating AgentsContrast MediaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProtonsComparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors
Khan MH, Mishra SK, Zakaria ABM, Mihailović J, Coman D, Hyder F. Comparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors. Analytical Chemistry 2022, 94: 2536-2545. PMID: 35073049, DOI: 10.1021/acs.analchem.1c04432.Peer-Reviewed Original ResearchConceptsLanthanide macrocyclic complexesParamagnetic lanthanide ionsMagnetic resonance agentsLanthanide complexesMacrocyclic complexesMacrocyclic designDownfield shiftLanthanide ionsNa NMRBulk magnetic susceptibility effectsUnpaired electronChelating agentBiomedical applicationsNegative chargeNMR sensorSodium ionsTriazacyclononaneIonsComplexesBiological importanceMacrocyclicTmDOTPNaCationsGd