Featured Publications
Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia
Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2020, 319: l661-l669. PMID: 32783617, PMCID: PMC7642899, DOI: 10.1152/ajplung.00316.2020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalExtracellular TrapsLungMiceNeutrophilsPhagocytosisPneumoniaPulmonary Disease, Chronic ObstructiveRespiratory Distress SyndromeConceptsNeutrophil extracellular trapsAcute respiratory distress syndromeChronic obstructive pulmonary diseaseNeutrophil responseExtracellular trapsDysregulation of neutrophilsObstructive pulmonary diseaseRespiratory distress syndromeNeutrophil effector functionsEx vivo assaysBronchoalveolar neutrophilsSevere asthmaDistress syndromeLung neutrophilsPulmonary diseaseMurine pneumoniaMurine modelEffector functionsNeutrophil researchMouse lungCystic fibrosisMethodologic issuesMurine researchLungArray of diseases
2011
Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes
Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology 2011, 54: 1790-1799. PMID: 21748767, PMCID: PMC3205211, DOI: 10.1002/hep.24548.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersBile Acids and SaltsBile CanaliculiCalciumCalcium SignalingCell Culture TechniquesCells, CulturedCholestasisCollagenDisease Models, AnimalHepatocytesInositol 1,4,5-Trisphosphate ReceptorsLipopolysaccharidesMaleProtein Processing, Post-TranslationalRatsRats, Sprague-DawleyConceptsBile salt secretionBSEP activityTrisphosphate receptorBile salt export pumpType II inositolSalt secretionPosttranslational regulationCell systemType 2 inositolCanalicular membraneCholesterol depletionIntrahepatic cholestasisConfocal immunofluorescenceFunctional polarityIntracellular calciumIsolated cell systemRat hepatocytesAnimal modelsSandwich cultureCollagen sandwich culturesPharmacologic inhibitionShort-term regulationCell membraneExport pumpSecretion