The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors
Chiu JE, Thekkiniath J, Mehta S, Müller C, Bracher F, Ben Mamoun C. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. Journal Of Biological Chemistry 2019, 294: 14757-14767. PMID: 31409644, PMCID: PMC6779428, DOI: 10.1074/jbc.ra119.009791.Peer-Reviewed Original ResearchMeSH KeywordsAmphotericin BAntifungal AgentsCoenzyme ADrug Resistance, FungalErgosterolGene Expression Regulation, FungalGenome, FungalPantothenic AcidPhosphotransferases (Alcohol Group Acceptor)Saccharomyces cerevisiaeSterolsTerbinafineConceptsErgosterol biosynthesis inhibitorsSterol intermediatesBiosynthesis inhibitorsErgosterol biosynthesis genesGenome-wide transcriptionMS-based analysisBiosynthesis genesResistant fungal pathogensMaster regulatorPlasma membraneFungal pathogensCoA biosynthesisErgosterol biosynthesisYeast cellsAntifungal drug terbinafinePantothenate utilizationSterol metabolismBiosynthesisAntifungal amphotericin BAcid utilizationCoA metabolismDrug interaction experimentsPrimary targetMetabolismEssential component