2021
Specific HLA alleles, paired with TCR V- and J-gene segment usage, link to distinct multiple myeloma survival rates
Huda TI, Mihyu M, Gozlan EC, Arndt MF, Diaz MJ, Zaman S, Chobrutskiy BI, Blanck G. Specific HLA alleles, paired with TCR V- and J-gene segment usage, link to distinct multiple myeloma survival rates. Leukemia & Lymphoma 2021, 62: 1711-1720. PMID: 33622167, DOI: 10.1080/10428194.2021.1885655.Peer-Reviewed Original ResearchConceptsHLA allele combinationsTCR VBlood samplesSurvival rateT cell receptor VOverall survival rateT cell characterizationSpecific HLA allelesLarger patient setsDistinct overall survival ratesSolid tumor typesSurvival distinctionsMM cohortHLA allelesJ-gene segment usageTumor typesPotential associationImmunogenomics studiesHLASegment usagePatient setAllele combinationsTCR recombinationImmunogenetic parametersImmunogenomic data
2019
Targeting Trop-2 in solid tumors: future prospects
Zaman S, Jadid H, Denson AC, Gray JE. Targeting Trop-2 in solid tumors: future prospects. OncoTargets And Therapy 2019, 12: 1781-1790. PMID: 30881031, PMCID: PMC6402435, DOI: 10.2147/ott.s162447.Peer-Reviewed Original ResearchAntibody-drug conjugatesTrop-2Clinical benefitClinical trialsTumor typesPlatinum-resistant urothelial cancerSmall cell lung cancerMultiple early-phase clinical trialsTriple-negative breast cancerEarly phase clinical trialsLimited treatment optionsTrop-2 expressionMultiple tumor typesUrothelial cancerTreatment optionsLung cancerBreast cancerSolid tumorsBaseline levelsCancer typesClinical useUpregulated expressionCancerTumorsNormal cells