2021
Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer
Slovak RJ, Park HJ, Kamp WM, Ludwig JM, Kang I, Kim HS. Co-inhibitor expression on tumor infiltrating and splenic lymphocytes after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Scientific Reports 2021, 11: 6956. PMID: 33772035, PMCID: PMC7997991, DOI: 10.1038/s41598-021-85810-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCD4-Positive T-LymphocytesCell Line, TumorCell ProliferationColorectal NeoplasmsCTLA-4 AntigenFemaleHepatitis A Virus Cellular Receptor 2Immune Checkpoint InhibitorsLymphocyte Activation Gene 3 ProteinLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred BALB CMicrosatellite RepeatsProgrammed Cell Death 1 ReceptorSpleenT-Lymphocytes, CytotoxicConceptsDual checkpoint inhibitionPD-1 inhibitionColorectal cancerCheckpoint inhibitionPD-1Checkpoint inhibitorsT cellsImmune responseRobust anti-tumor immune responseAnti-PD-1 groupAnti-PD-1 antibodyAnti-tumor immune responseMicrosatellite stable colorectal cancerDual PD-1Majority of patientsDeficient mismatch repairStable colorectal cancerCTLA-4 inhibitionTumor growth rateHigh microsatellite instabilityPotential escape mechanismsCombination immunotherapyImmunosuppressive checkpointsTumoral infiltrationDual therapy
2020
3:00 PM Abstract No. 190 ■ FEATURED ABSTRACT Quantifying the immune response after combined immuno-thermal ablation in a murine model of colorectal cancer
Slovak R, Park H, Kamp W, Ludwig J, Kang I, Kim K. 3:00 PM Abstract No. 190 ■ FEATURED ABSTRACT Quantifying the immune response after combined immuno-thermal ablation in a murine model of colorectal cancer. Journal Of Vascular And Interventional Radiology 2020, 31: s87. DOI: 10.1016/j.jvir.2019.12.229.Peer-Reviewed Original ResearchQuantification of immune response after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer.
Kamp W, Park H, Slovak R, Ludwig J, Kang I, Kim H. Quantification of immune response after dual checkpoint inhibition in a microsatellite stable model of colorectal cancer. Journal Of Clinical Oncology 2020, 38: 160-160. DOI: 10.1200/jco.2020.38.4_suppl.160.Peer-Reviewed Original ResearchDual immune checkpoint blockadeAnti-PD-1 antibodyColorectal cancerPD-1T cellsImmune responseMurine colorectal cancer cellsBALB/c miceDual checkpoint inhibitionExpression of TIM3Subcutaneous flank injectionNumber of CD8PD-1 inhibitionImmune checkpoint blockadeDeficient mismatch repairColorectal cancer cellsHigh microsatellite instabilitySignificant clinical impactPotential escape mechanismsCombination immunotherapyImmunosuppressive checkpointsCheckpoint inhibitorsMonotherapy groupCheckpoint blockadeMost patientsSystemic impact on tumor growth after combined immuno-thermal ablation in a murine model of colorectal cancer.
Slovak R, Park H, Kamp W, Ludwig J, Kang I, Kim H. Systemic impact on tumor growth after combined immuno-thermal ablation in a murine model of colorectal cancer. Journal Of Clinical Oncology 2020, 38: 198-198. DOI: 10.1200/jco.2020.38.4_suppl.198.Peer-Reviewed Original ResearchDual immune checkpoint blockadeTreatment days 0Target tumorTumor volumeDay 0Anti-cancer immune responseBALB/c miceAddition of immunotherapyImmune checkpoint blockadeTreatment day 2Colorectal cancer cellsInjection of antibodiesFull ablationCheckpoint blockadeColorectal cancerC miceSham injectionMean changeImmune responseMurine modelControl animalsCryoablationDay 2Tumor growthFlank injection
2019
Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies
Case M, Slovak R, Raja J, Kim H. Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies. Digestive Disease Interventions 2019, 03: 155-162. DOI: 10.1055/s-0039-1679936.Peer-Reviewed Original ResearchTranscatheter therapyImmune responseSystemic immunotherapyInterventional oncologyHepatic artery infusionImmunologic effectsTranscatheter embolizationTranscatheter treatmentTreatment paradigmMultiple malignanciesRadiation therapyTherapyImmunotherapyOncologyPotential effectsChemoembolizationEmbolizationResponseChemotherapyRadioembolizationMalignancyInfusionCancerInterventional Oncology in Immuno-Oncology Part 1: Thermal Ablation
Slovak R, Raja J, Case M, Kim H. Interventional Oncology in Immuno-Oncology Part 1: Thermal Ablation. Digestive Disease Interventions 2019, 03: 143-154. DOI: 10.1055/s-0039-1679935.Peer-Reviewed Original ResearchImmune responseThermal ablationSitu tumor vaccineSystemic immunological effectsAnticancer immune responseAdaptive immune responsesFocused ultrasound ablationTumor vaccinesImmunological effectsAblative techniquesInterventional oncologyInvasive formUltrasound ablationAblationResponseMonotherapyPalliationImmunotherapyCryoablationMalignancyVaccineOncology
2017
Immuno-thermal ablations – boosting the anticancer immune response
Slovak R, Ludwig JM, Gettinger SN, Herbst RS, Kim HS. Immuno-thermal ablations – boosting the anticancer immune response. Journal For ImmunoTherapy Of Cancer 2017, 5: 78. PMID: 29037259, PMCID: PMC5644150, DOI: 10.1186/s40425-017-0284-8.Peer-Reviewed Original ResearchConceptsImmune responseImmune effectsRobust antitumor responseAnticancer immune responseImmune modulating drugsUse of immunomodulationSystemic antitumor activityCheckpoint blockadeAntitumor responseAblative therapyCombination therapyRadiofrequency ablationAblative techniquesModulating drugsAnimal modelsAntitumor activityThermal ablationTherapeutic appealImmunomodulationTherapyAblationResponseMonotherapyImmunomodulatorsCryoablation