Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
Kim HN, Xiong J, MacLeod RS, Iyer S, Fujiwara Y, Cawley KM, Han L, He Y, Thostenson JD, Ferreira E, Jilka RL, Zhou D, Almeida M, O'Brien CA. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight 2020, 5: e138815. PMID: 32870816, PMCID: PMC7566701, DOI: 10.1172/jci.insight.138815.Peer-Reviewed Original ResearchConceptsCortical bone lossBone lossControl miceAged miceCortical boneAge-associated bone lossOsteoclastogenic cytokine RANKLOsteocyte-derived RANKLTrabecular boneMonths of ageSenescent cellsConditional knockout miceHuman cell culture modelsRANKL levelsCytokine RANKLRANKL productionKnockout miceTranscription factor GATA4Cell culture modelSenolytic compoundsRANKLMiceAgeBoneCellular senescenceLocal Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption
Cawley KM, Bustamante-Gomez NC, Guha AG, MacLeod RS, Xiong J, Gubrij I, Liu Y, Mulkey R, Palmieri M, Thostenson JD, Goellner JJ, O’Brien C. Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell Reports 2020, 32: 108052. PMID: 32905775, PMCID: PMC7493998, DOI: 10.1016/j.celrep.2020.108052.Peer-Reviewed Original Research