2024
Evolutionary Medicine
Stearns S, Medzhitov R. Evolutionary Medicine. 2024 DOI: 10.1093/oso/9780192871978.001.0001.Peer-Reviewed Original ResearchRisk of metastasisPlacental invasionSolid tumorsEvolution of reproductionMental disordersAdaptive therapyPublic healthVaccine developmentEvolution of agingSick personEvolutionary historyEvolutionary insightsPhage therapyPathogen emergenceIndependent evolutionEvolutionary hypothesesHealthEvolutionary aspectsTherapyCancerDiseaseEvolutionary medicineMedical researchChildbirth
2023
An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis
Wang S, Li K, Pickholz E, Dobie R, Matchett K, Henderson N, Carrico C, Driver I, Borch Jensen M, Chen L, Petitjean M, Bhattacharya D, Fiel M, Liu X, Kisseleva T, Alon U, Adler M, Medzhitov R, Friedman S. An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis. Science Translational Medicine 2023, 15: eadd3949. PMID: 36599008, PMCID: PMC10686705, DOI: 10.1126/scitranslmed.add3949.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsAdvanced hepatic fibrosisNonalcoholic steatohepatitisAdvanced fibrosisHepatic fibrosisHSC activationStellate cellsMurine nonalcoholic steatohepatitisStage-specific therapyHuman nonalcoholic steatohepatitisHuman HSC activationNeurotrophic receptor tyrosine kinaseDrug targetsSingle-nucleus RNA sequencingAdvanced diseaseAntifibrotic efficacyAntifibrotic therapyFibrosisTherapeutic paradigmAutocrine interactionsPharmacological inhibitionReceptor tyrosine kinasesSteatohepatitisStrongest predictorTherapy