2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial
Branch-Elliman W, Ferguson R, Doros G, Woods P, Leatherman S, Strymish J, Datta R, Goswami R, Jankowich MD, Shah NR, Taylor TH, Page ST, Schiller SJ, Shannon C, Hau C, Flynn M, Holmberg E, Visnaw K, Dhond R, Brophy M, Monach PA. Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. PLOS ONE 2022, 17: e0263591. PMID: 35213547, PMCID: PMC8880885, DOI: 10.1371/journal.pone.0263591.Peer-Reviewed Original ResearchConceptsStandard of careSubcutaneous sarilumabMechanical ventilationSevere COVID-19 diseaseHospitalized COVID-19 patientsDays of randomizationIL-6R inhibitionRate of intubationTrial of patientsSevere COVID-19COVID-19 patientsNumber of patientsVA Medical CenterAnti-inflammatory drugsCOVID-19SARS-CoV-2COVID-19 diseaseData monitoring committeeEligible patientsPrimary endpointSOC armPrimary outcomeRespiratory compromiseElectronic health record systemsClinical criteria
2021
Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection
Weiss JJ, Attuquayefio TN, White EB, Li F, Herz RS, White TL, Campbell M, Geng B, Datta R, Wyllie AL, Grubaugh ND, Casanovas-Massana A, Muenker MC, Moore AJ, Handoko R, Iwasaki A, Martinello RA, Ko AI, Small DM, Farhadian SF, Team T. Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0248025. PMID: 33657167, PMCID: PMC7928484, DOI: 10.1371/journal.pone.0248025.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2 positive healthcare workersSmell lossHealthcare workersHome assessmentNeurological symptomsPositive SARS-CoV-2 testSARS-CoV-2 test positivitySARS-CoV-2 testPolymerase chain reaction testingReal-time quantitative polymerase chain reaction testingQuantitative polymerase chain reaction testingCOVID-19 patientsHigh-risk groupHigh-risk individualsSARS-CoV-2Self-reported changesProspective studyTest positivityAsymptomatic infectionSymptom SurveyVulnerable patientsHigh riskPositive testRisk individuals
2020
Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia
Gautam S, Cohen AJ, Stahl Y, Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.Peer-Reviewed Original ResearchConceptsPure viral infectionBacterial coinfectionViral infectionInfluenza infectionSevere respiratory viral infectionsAbility of procalcitoninRetrospective cohort studyViral respiratory infectionsRespiratory viral infectionsMarker of severityRespiratory viral illnessSevere viral infectionsSpecificity of procalcitoninCharacteristic curve analysisCellular modelHigher procalcitoninProcalcitonin expressionElevated procalcitoninCohort studyViral illnessRespiratory infectionsAntibiotic administrationBacterial pneumoniaSevere diseaseProcalcitonin
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2018
Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults
Datta R, Helou E, Tucker M, John B, Martinello RA, Malinis M. Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults. Infection Control And Hospital Epidemiology 2018, 39: 1145-1147. PMID: 29945685, PMCID: PMC6540757, DOI: 10.1017/ice.2018.147.Peer-Reviewed Case Reports and Technical NotesMenace Elbow: Disseminated Nocardiosis
Datta R, Kramer E, Reinhart H, Campbell S, Wong E, Gupta S. Menace Elbow: Disseminated Nocardiosis. The American Journal Of Medicine 2018, 131: 1307-1309. PMID: 29729234, PMCID: PMC6482376, DOI: 10.1016/j.amjmed.2018.04.012.Peer-Reviewed Case Reports and Technical Notes
2015
Quantifying the Exposure to Antibiotic-Resistant Pathogens Among Patients Discharged From a Single Hospital Across All California Healthcare Facilities
Datta R, Brown S, Nguyen VQ, Cao C, Billimek J, Avery T, Lee BY, Huang SS. Quantifying the Exposure to Antibiotic-Resistant Pathogens Among Patients Discharged From a Single Hospital Across All California Healthcare Facilities. Infection Control And Hospital Epidemiology 2015, 36: 1275-1282. PMID: 26387690, DOI: 10.1017/ice.2015.181.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsCaliforniaCarrier StateClostridiumCross InfectionDrug Resistance, BacterialFemaleHospitalsHumansKlebsiella pneumoniaeLength of StayMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedNursing HomesPatient DischargePatient ReadmissionRetrospective StudiesVancomycin-Resistant EnterococciYoung AdultConceptsMethicillin-resistant Staphylococcus aureusClostridium difficile infectionVancomycin-resistant enterococciNursing homesAntibiotic-resistant pathogensDays of dischargeHealthcare facilitiesLength of stayExtended-spectrum β-lactamaseYear of dischargeMultiple cohort studiesTime-dependent exposureESBL carriersMore readmissionsCDI patientsHospital readmissionDifficile infectionSingle hospitalReadmissionHospitalPatientsKlebsiella pneumoniaeΒ-lactamaseStaphylococcus aureusNoncarriersSubstantial Variation in Hospital Rankings after Adjusting for Hospital-Level Predictors of Publicly-Reported Hospital-Associated Clostridium difficile Infection Rates
Datta R, Kazerouni NN, Rosenberg J, Nguyen VQ, Phelan M, Billimek J, Cao C, McLendon P, Cummings K, Huang SS. Substantial Variation in Hospital Rankings after Adjusting for Hospital-Level Predictors of Publicly-Reported Hospital-Associated Clostridium difficile Infection Rates. Infection Control And Hospital Epidemiology 2015, 36: 464-466. PMID: 25782902, DOI: 10.1017/ice.2014.83.Peer-Reviewed Original ResearchConceptsClostridium difficile infection ratesDifficile infection ratesLong-term acute care hospitalInfection ratePolymerase chain reaction testingHospital-level predictorsHospital-level characteristicsAcute care hospitalsCare hospitalCommunity hospitalLTAC hospitalTeaching hospitalLicensed bedsReaction testingHospitalCalifornia hospitalsHospital rankings
2014
Substantial Shifts in Ranking of California Hospitals by Hospital-Associated Methicillin-Resistant Staphylococcus aureus Infection Following Adjustment for Hospital Characteristics and Case Mix
Tehrani DM, Phelan MJ, Cao C, Billimek J, Datta R, Nguyen H, Kwark H, Huang SS. Substantial Shifts in Ranking of California Hospitals by Hospital-Associated Methicillin-Resistant Staphylococcus aureus Infection Following Adjustment for Hospital Characteristics and Case Mix. Infection Control And Hospital Epidemiology 2014, 35: 1263-1270. PMID: 25203180, DOI: 10.1086/678069.Peer-Reviewed Original ResearchConceptsHA-MRSA infectionsCase mixHospital rankingsCalifornia acute care hospitalsHospital-Associated MethicillinRetrospective cohort studyMethicillin-resistant Staphylococcus aureusAcute care hospitalsFacility-level characteristicsPatient population characteristicsFacility-level factorsMandatory hospitalizationMRSA pneumoniaSerious comorbiditiesCohort studyCare hospitalHospital proportionHospital characteristicsCommunity hospitalPopulation characteristicsHospital case mixAdmissionInfection prevention performanceHospitalInfection riskProtective Effect of Methicillin-Susceptible Staphylococcus aureus Carriage against Methicillin-Resistant S. aureus Acquisition in Nursing Homes: A Prospective Cross-Sectional Study
Datta R, Quan V, Kim D, Peterson EM, Reynolds C, Meyers H, Cheung M, Huang SS. Protective Effect of Methicillin-Susceptible Staphylococcus aureus Carriage against Methicillin-Resistant S. aureus Acquisition in Nursing Homes: A Prospective Cross-Sectional Study. Infection Control And Hospital Epidemiology 2014, 35: 1257-1262. PMID: 25203179, DOI: 10.1086/678062.Peer-Reviewed Original ResearchConceptsProspective cross-sectional studyCross-sectional studyS. aureus prevalencePoint prevalenceAdmission prevalenceNursing homesAureus prevalenceInverse associationMethicillin-resistant S. aureus (MRSA) prevalenceS. aureus acquisitionMethicillin-susceptible Staphylococcus aureus (MSSA) carriageDay of admissionStaphylococcus aureus carriageNursing home stayBlood agarMinimal associationMSSA carriageAureus carriageMRSA acquisitionPercentage of residentsNares swabsProtective effectSkin lesionsTotal swabsSheep blood agar
2013
High Nasal Burden of Methicillin-Resistant Staphylococcus aureus Increases Risk of Invasive Disease
Datta R, Shah A, Huang SS, Cui E, Nguyen V, Welbourne SJ, Quan KA, Thrupp L. High Nasal Burden of Methicillin-Resistant Staphylococcus aureus Increases Risk of Invasive Disease. Journal Of Clinical Microbiology 2013, 52: 312-314. PMID: 24153126, PMCID: PMC3911445, DOI: 10.1128/jcm.01606-13.Peer-Reviewed Original ResearchDiscord among Performance Measures for Central Line—Associated Bloodstream Infection
Tehrani DM, Russell D, Brown J, Boynton-Delahanty K, Quan K, Gibbs L, Braddock G, Zaroda T, Koopman M, Thompson D, Nichols A, Cui E, Liu C, Cohen S, Rubin Z, Pegues D, Torriani F, Datta R, Huang SS. Discord among Performance Measures for Central Line—Associated Bloodstream Infection. Infection Control And Hospital Epidemiology 2013, 34: 176-183. PMID: 23295564, DOI: 10.1086/669090.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultAgedAged, 80 and overBacteremiaCaliforniaCatheter-Related InfectionsCenters for Medicare and Medicaid Services, U.S.Clinical CodingCross InfectionFemaleHumansInsurance Claim ReviewMaleMandatory ProgramsMedical AuditMiddle AgedRetrospective StudiesUnited StatesYoung AdultConceptsCentral line-associated bloodstream infectionsChart reviewConsecutive patientsBloodstream infectionsNHSN criteriaClaims codesCommon reasonNational Healthcare Safety Network criteriaCentral Line–Associated Bloodstream InfectionsMulticenter retrospective cohort studyLine–Associated Bloodstream InfectionsLine-associated bloodstream infectionsRetrospective cohort studyMedical record reviewCLABSI eventsCLABSI reportingCohort studyRecord reviewPrevention criteriaClaims dataNetwork criteriaPhysician documentationClaims cohortPatientsDisease control
2011
Methicillin-Resistant Staphylococcus aureus Infection and Hospitalization in High-Risk Patients in the Year following Detection
Huang SS, Hinrichsen VL, Datta R, Spurchise L, Miroshnik I, Nelson K, Platt R. Methicillin-Resistant Staphylococcus aureus Infection and Hospitalization in High-Risk Patients in the Year following Detection. PLOS ONE 2011, 6: e24340. PMID: 21949707, PMCID: PMC3174953, DOI: 10.1371/journal.pone.0024340.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureus (MRSA) infectionsPost-discharge infectionsStaphylococcus aureus infectionMRSA infectionHealthcare utilizationAureus infectionTertiary care medical centerPrimary bloodstream infectionsRetrospective cohort studyHigh-risk patientsTertiary care patientsHarvard Pilgrim Health CareSubstantial attributable mortalitySingle hospitalizationMRSA carriageMRSA carriersAdult patientsCohort studyHospital dischargeSubsequent readmissionCare patientsAttributable mortalityBloodstream infectionsCommon infectionsMost infectionsColonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study
Huang SS, Datta R, Rifas-Shiman S, Kleinman K, Placzek H, Lankiewicz JD, Platt R. Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study. Critical Care 2011, 15: r210. PMID: 21914221, PMCID: PMC3334754, DOI: 10.1186/cc10445.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusMethicillin-sensitive Staphylococcus aureusVancomycin-resistant enterococciInitial negative swabCase-control studyVancomycin-sensitive enterococciMRSA acquisitionVRE acquisitionICU admissionRisk factorsNegative swabsStaphylococcus aureusHigh endemic settingMRSA-positive patientsVancomycin-resistant enterococci acquisitionThird-generation cephalosporinsSensitive strainsPredictors of acquisitionBilateral naresMSSA carriageMSSA infectionsSame hospitalizationICU patientsLow albuminMRSA infectionUse of Medicare Claims to Rank Hospitals by Surgical Site Infection Risk following Coronary Artery Bypass Graft Surgery
Huang SS, Placzek H, Livingston J, Ma A, Onufrak F, Lankiewicz J, Kleinman K, Bratzler D, Olsen MA, Lyles R, Khan Y, Wright P, Yokoe DS, Fraser VJ, Weinstein RA, Stevenson K, Hooper D, Vostok J, Datta R, Nsa W, Platt R. Use of Medicare Claims to Rank Hospitals by Surgical Site Infection Risk following Coronary Artery Bypass Graft Surgery. Infection Control And Hospital Epidemiology 2011, 32: 775-783. PMID: 21768761, DOI: 10.1086/660874.Peer-Reviewed Original ResearchConceptsWorst decileSSI ratesMedicare beneficiariesCoronary artery bypass graft surgeryArtery bypass graft surgerySurgical site infection rateSurgical site infection riskBypass graft surgeryRetrospective cohort studyCoronary artery bypassMedical record reviewDay of surgeryAdjusted odds ratioService Medicare beneficiariesQuality of careArtery bypassGraft surgeryCohort studySSI riskRecord reviewGroup of hospitalsCurrent surveillance methodsMedical recordsOdds ratioMedicare claimsEnvironmental Cleaning Intervention and Risk of Acquiring Multidrug-Resistant Organisms From Prior Room Occupants
Datta R, Platt R, Yokoe DS, Huang SS. Environmental Cleaning Intervention and Risk of Acquiring Multidrug-Resistant Organisms From Prior Room Occupants. JAMA Internal Medicine 2011, 171: 491-494. PMID: 21444840, DOI: 10.1001/archinternmed.2011.64.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusRisk of acquisitionPrior room occupantsVancomycin-resistant enteroccociIntensive care unitCare unitIntervention periodAcquisition of MRSAIntensive care unit roomsRetrospective cohort studyMultidrug-resistant organismsAcademic medical centerEnvironmental cleaning interventionsVRE acquisitionEligible patientsMRSA carriersVRE transmissionCardiac surgeryCohort studyMRSA acquisitionNeurosurgery unitThoracic surgeryMedical CenterVRE carriersGeneral surgery
2010
Risk of Postdischarge Infection with Vancomycin-Resistant Enterococcus after Initial Infection or Colonization
Datta R, Huang SS. Risk of Postdischarge Infection with Vancomycin-Resistant Enterococcus after Initial Infection or Colonization. Infection Control And Hospital Epidemiology 2010, 31: 1290-1293. PMID: 20979493, PMCID: PMC3075426, DOI: 10.1086/657332.Peer-Reviewed Original Research
2008
Risk of Infection and Death due to Methicillin- Resistant Staphylococcus aureus in Long-Term Carriers
Datta R, Huang SS. Risk of Infection and Death due to Methicillin- Resistant Staphylococcus aureus in Long-Term Carriers. Clinical Infectious Diseases 2008, 47: 176-181. PMID: 18532892, PMCID: PMC2649874, DOI: 10.1086/589241.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBacteremiaBostonCarrier StateCatheterization, Central VenousCohort StudiesFemaleHospitalizationHumansLogistic ModelsMaleMethicillin ResistanceMiddle AgedPneumoniaRetrospective StudiesRisk FactorsSex FactorsSoft Tissue InfectionsStaphylococcal InfectionsStaphylococcus aureusTime FactorsConceptsMethicillin-resistant Staphylococcus aureusLong-term carriersRisk of infectionMRSA infectionSingle-center retrospective cohort studyCentral venous catheter infectionSubsequent MRSA infectionVenous catheter infectionRetrospective cohort studyShort-term morbiditySoft tissue infectionsDuration of carriageStaphylococcus aureusMRSA colonizationCohort studyCatheter infectionCommon infectionsNew hospitalizationHigh riskSubsequent infectionTime of detectionPersistent riskInfectionSignificant riskDeath