2023
IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory
Micevic G, Daniels A, Flem-Karlsen K, Park K, Talty R, McGeary M, Mirza H, Blackburn H, Sefik E, Cheung J, Hornick N, Aizenbud L, Joshi N, Kluger H, Iwasaki A, Bosenberg M, Flavell R. IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2304319120. PMID: 37459511, PMCID: PMC10372654, DOI: 10.1073/pnas.2304319120.Peer-Reviewed Original ResearchConceptsIL-7R expressionT cellsIL-7RAntitumor memorySuperior antitumor efficacyCell-based therapiesTumor-specific T cellsAntigen-specific T cellsAntitumor efficacyPowerful antitumor immune responseMarkers of exhaustionTumor-specific CD8Antitumor immune responseIndependent prognostic factorAntitumor immune memoryMemory T cellsMajor risk factorSuperior antitumor activityFunctional CD8Memory CD8Prognostic factorsSurgical resectionAdvanced melanomaLymph nodesNaive miceDiscovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations
Yan H, Talty R, Jain A, Cai Y, Zheng J, Shen X, Muca E, Paty P, Bosenberg M, Khan S, Johnson C. Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations. Redox Biology 2023, 62: 102699. PMID: 37086630, PMCID: PMC10172914, DOI: 10.1016/j.redox.2023.102699.Peer-Reviewed Original ResearchConceptsKRAS mutant tumorsMale CRC patientsCRC patientsMale patientsKRAS mutationsMutant tumorsOverall survivalMale colorectal cancer patientsKRAS wild-type tumorsAberrant tumor metabolismColorectal cancer patientsCRC patient cohortsColorectal cancer casesFerroptosis-related genesWild-type tumorsNovel potential avenuesNormal colon tissuesPoor OSKRAS statusAdverse outcomesCRC cellsPatient cohortCancer patientsType tumorsCancer casesFerroptosis in colorectal cancer: a future target?
Yan H, Talty R, Aladelokun O, Bosenberg M, Johnson C. Ferroptosis in colorectal cancer: a future target? British Journal Of Cancer 2023, 128: 1439-1451. PMID: 36703079, PMCID: PMC10070248, DOI: 10.1038/s41416-023-02149-6.Peer-Reviewed Original ResearchConceptsColorectal cancerRegulated cell deathCurrent treatment optionsForms of RCDCancer deathTreatment optionsCRC therapyCancer recurrenceTreatment strategiesRadiation therapyOvert toxicityTherapeutic targetDrug resistanceTherapyCancer cellsFerroptosisPotential roleCancerCell deathFuture targetsDeathRecent studiesBiological pathwaysChemotherapySurgery
2022
Targeting ferroptosis to treat colorectal cancer
Yan H, Talty R, Johnson C. Targeting ferroptosis to treat colorectal cancer. Trends In Cell Biology 2022, 33: 185-188. PMID: 36473802, DOI: 10.1016/j.tcb.2022.11.003.Peer-Reviewed Original ResearchConceptsProtein kinase BArachidonic acidColorectal cancer treatmentProtein kinaseKinase BMammalian targetKey pathwaysGlutathione metabolismFerroptosis inductionEnergy metabolismCRC treatmentColorectal cancerCRC pathogenesisFerroptosisCancer treatmentPromising targetNew conceptual avenuesMetabolismTreatmentHippoKinasePrimary strategyRapamycinTargetConceptual avenues
2021
The role of ferroptosis in melanoma
Talty R, Bosenberg M. The role of ferroptosis in melanoma. Pigment Cell & Melanoma Research 2021, 35: 18-25. PMID: 34407291, DOI: 10.1111/pcmr.13009.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsNovel therapeutic targetIron-dependent regulated cell deathContext of melanomaRole of ferroptosisDysregulation of ferroptosisForms of cancerCheckpoint inhibitorsAdvanced melanomaImmunotherapy regimensMelanoma patientsTargeted therapyTherapeutic targetSkin cancerMelanomaDeadliest formTherapyRegulated cell deathFerroptosisPatientsCancerCell deathCurrent literatureRegimensRelapseModification and application of the proximal humerus ossification system to adolescent idiopathic scoliosis patients
Li DT, Li E, Cui JJ, Kahan JB, Petit L, Adeclat GJ, Modrak M, Talty R, Greene JD, Munger AM, Nicholson AD, Cravez E, Cooperman DR, Smith BG. Modification and application of the proximal humerus ossification system to adolescent idiopathic scoliosis patients. Spine Deformity 2021, 9: 1341-1348. PMID: 33939168, DOI: 10.1007/s43390-021-00338-y.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisMedial physisCobb angleSurgical rangeLateral physisStage 3aIdiopathic scoliosisPercentage of patientsIdiopathic scoliosis patientsInter-observer ICCStage 3bInitial presentationPhyseal closureScoliosis patientsHigh riskPatientsSkeletal maturityPhysisHeight velocityRadiographsPeak height velocityProgressionSurgeryHigh rateScoliosis
2019
The Proximal Humeral Ossification System Improves Assessment of Maturity in Patients with Scoliosis.
Li DT, Linderman GC, Cui JJ, DeVries S, Nicholson AD, Li E, Petit L, Kahan JB, Talty R, Kluger Y, Cooperman DR, Smith BG. The Proximal Humeral Ossification System Improves Assessment of Maturity in Patients with Scoliosis. Journal Of Bone And Joint Surgery 2019, 101: 1868-1874. PMID: 31626012, PMCID: PMC7515481, DOI: 10.2106/jbjs.19.00296.Peer-Reviewed Original Research