2019
Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function
Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function. Communications Biology 2019, 2: 113. PMID: 30937396, PMCID: PMC6433901, DOI: 10.1038/s42003-019-0355-0.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumClaudin-19Retinal neurogenesisP1 waveOuter nuclear layerRPE signature genesARPE19 cell lineOcular involvementKidney diseaseVisual functionFamilial hypomagnesaemiaNuclear layerBipolar cellsNewborn miceOcular diseasesPigment epitheliumRetinal isomeraseDiseaseMiceHuman induced pluripotent cellsRetinal differentiationSignature genesCell linesNeurogenesisInduced pluripotent cells
2013
Prevalence of Ocular Manifestations of HIV/AIDS in the Highly Active Antiretroviral Therapy (HAART) Era: A Different Spectrum in Central South China
Luo J, Jing D, Kozak I, Huiming Z, Siying C, Yezhen Y, xin Q, Luosheng T, Adelman RA, Forster SH. Prevalence of Ocular Manifestations of HIV/AIDS in the Highly Active Antiretroviral Therapy (HAART) Era: A Different Spectrum in Central South China. Ophthalmic Epidemiology 2013, 20: 170-175. PMID: 23713918, DOI: 10.3109/09286586.2013.789530.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntiretroviral Therapy, Highly ActiveAsian PeopleCD4 Lymphocyte CountCD4-Positive T-LymphocytesChildChinaCross-Sectional StudiesCytomegalovirus RetinitisEye Infections, ViralFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceRetinal DiseasesRisk FactorsVisual AcuityYoung AdultConceptsHIV/AIDSOcular manifestationsActive antiretroviral therapy (HAART) eraHuman immunodeficiency virus/Antiretroviral therapy eraActive antiretroviral therapyRoutine ophthalmic examinationEra of HAARTPrevalence of HIVCross-sectional studyHIV retinopathyTherapy eraAntiretroviral therapyCommon HIVCytomegalovirus retinitisOcular complicationsOcular examinationOcular findingsImmunodeficiency syndromeOcular lesionsOphthalmic examinationVirus/Epidemiologic studiesHigh riskOcular diseases
2012
Effects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment EpitheliumCytokine Effects on RPE Tight Junctions
Peng S, Gan G, Rao VS, Adelman RA, Rizzolo LJ. Effects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment EpitheliumCytokine Effects on RPE Tight Junctions. Investigative Ophthalmology & Visual Science 2012, 53: 5016-5028. PMID: 22761260, PMCID: PMC3410691, DOI: 10.1167/iovs.11-8311.Peer-Reviewed Original ResearchConceptsHuman fetal RPEEffects of TNFαTransepithelial electrical resistanceProinflammatory cytokinesClaudin-19Tight junctionsAge-related macular degenerationZO-1Effects of cytokinesApical sideSubclinical inflammationTumor necrosisMacular degenerationTNFα receptorsOcular diseasesTNFαSerum-free mediumClaudin-3RPE tight junctionsFetal RPECytokinesClaudin-2Confocal immunofluorescence microscopyInhibitor of apoptosis