2024
Comparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial
Zelenev A, Huedo-Medina T, Shrestha R, Mistler C, Altice F, Sibilio B, Copenhaver M. Comparing the brief Holistic Health for HIV (3H+) to the Holistic Health Recovery Program (HHRP+) among people with HIV and opioid use disorder: Results from a randomized, controlled non-inferiority trial. PLOS ONE 2024, 19: e0312165. PMID: 39509356, PMCID: PMC11542883, DOI: 10.1371/journal.pone.0312165.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHolistic HealthHumansMaleMedication AdherenceMiddle AgedOpioid-Related DisordersRisk-TakingConceptsHolistic Health Recovery ProgramEvidence-based interventionsHolistic healthHIV treatmentRisk behaviorsReduce HIV risk behaviorsDifference-in-differencesEnd-of-interventionControlled non-inferiority trialHIV Epidemic goalsDrug treatment settingsAttainment of viral suppressionNon-inferiority trialRecovery programViral suppressionHigh ART adherenceHIV risk behaviorsNon-inferiorityHHRP+ART adherenceBehavioral interventionsReal-world settingsNon-parametric bootstrappingCondom useOpioid-dependent people
2023
Application of the multiphase optimisation strategy (MOST) to optimise HIV prevention targeting people on medication for opioid use disorder (MOUD) who have cognitive dysfunction: protocol for a MOST study
Mistler C, Shrestha R, Gunstad J, Collins L, Madden L, Huedo-Medina T, Sibilio B, Copenhaver N, Copenhaver M. Application of the multiphase optimisation strategy (MOST) to optimise HIV prevention targeting people on medication for opioid use disorder (MOUD) who have cognitive dysfunction: protocol for a MOST study. BMJ Open 2023, 13: e071688. PMID: 37399447, PMCID: PMC10314648, DOI: 10.1136/bmjopen-2023-071688.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCognitive DysfunctionHIV InfectionsHumansOpioid-Related DisordersPre-Exposure ProphylaxisSubstance Abuse, IntravenousConceptsOpioid use disorderMultiphase optimization strategyCognitive dysfunctionHIV preventionUse disordersPromising biomedical interventionsPre-exposure prophylaxisHIV incidence ratesHIV risk reductionHIV prevention interventionsDrug treatment settingsInstitutional review boardInformed consent formPrEP adherenceHIV prevention contentHIV infectionPrEP uptakeStudy protocolIncidence rateRisk groupsPrevention interventionsPWIDTreatment settingsReview boardEffective interventions
2022
Using nominal group technique to identify barriers and facilitators to preventing HIV using combination same-day pre-exposure prophylaxis and medications for opioid use disorder
Eger WH, Altice FL, Lee J, Vlahov D, Khati A, Osborne S, Wickersham JA, Bohonnon T, Powell L, Shrestha R. Using nominal group technique to identify barriers and facilitators to preventing HIV using combination same-day pre-exposure prophylaxis and medications for opioid use disorder. Harm Reduction Journal 2022, 19: 120. PMID: 36307817, PMCID: PMC9616614, DOI: 10.1186/s12954-022-00703-8.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsHIV InfectionsHumansOpioid-Related DisordersPre-Exposure ProphylaxisSubstance Abuse, IntravenousConceptsSame-day prescriptionPre-exposure prophylaxisOpioid use disorderHIV transmissionUse disordersClinical stakeholdersAvailability of providersSystems of careHealth care systemCoordinated careNew practice modelClinical careMedicationsPharmacy deliveryMOUDNominal group techniqueLocal prescribersPWIDSexual riskPrEPCare systemHealth benefitsCareMultiple visitsProphylaxisLatent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment
Gunstad J, Disabato D, Shrestha R, Sanborn V, Mistler CB, Copenhaver MM. Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment. Journal Of Addictive Diseases 2022, 41: 120-127. PMID: 35615880, PMCID: PMC9699904, DOI: 10.1080/10550887.2022.2080626.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineCognitionCognitive DysfunctionHumansMethadoneOpiate Substitution TreatmentOpioid-Related DisordersConceptsLatent profile analysisNeurocognitive dysfunctionBrief inventoryNeuro-cognitive profileNeuro-cognitive impairmentSelf-reported neurocognitive symptomsProfile analysisOpioid-dependent patientsOpioid use disorderTreatment outcomesNeurocognitive impairmentDrug treatment outcomesMultiple domainsTreatment programUse disordersIntervention strategiesIndividual treatment needsNeurocognitive symptomsDrug treatment settingsTreatment settingsMethadone maintenance treatment programAccommodation strategiesModerate concernMaintenance treatment programOptimal treatment outcomesRace, Trust, and COVID-19 Vaccine Hesitancy in People with Opioid Use Disorder
Sullivan MC, Mistler C, Copenhaver MM, Wickersham JA, Ni Z, Kim RS, Shrestha R. Race, Trust, and COVID-19 Vaccine Hesitancy in People with Opioid Use Disorder. Health Psychology 2022, 41: 115-120. PMID: 34855415, PMCID: PMC9754617, DOI: 10.1037/hea0001120.Peer-Reviewed Original ResearchMeSH KeywordsAdultCOVID-19COVID-19 VaccinesFemaleHumansMaleOpioid-Related DisordersPandemicsSARS-CoV-2TrustVaccinationVaccination HesitancyConceptsOpioid use disorderMethadone maintenance programEffective vaccineVaccine hesitancyUse disordersCOVID-19 vaccine hesitancyInjection drug useEffective COVID-19 vaccineCoronavirus disease 2019COVID-19 vaccineCOVID-19Sexual risk behaviorsSocial risk factorsVaccine uptakeRisk factorsVaccination willingnessRisk groupsDisease 2019Psychosocial factorsDrug useProactive outreachPhysician ScaleRisk behaviorsHealth disparitiesVaccineClinical and Demographic Differences in the Willingness to use Self-Administered At-Home COVID-19 Testing Measures among Persons with Opioid use Disorder
Mistler CB, Sullivan M, Wickersham JA, Copenhaver MM, Shrestha R. Clinical and Demographic Differences in the Willingness to use Self-Administered At-Home COVID-19 Testing Measures among Persons with Opioid use Disorder. Substance Use & Addiction Journal 2022, 43: 708-712. PMID: 35100084, PMCID: PMC9725184, DOI: 10.1080/08897077.2021.2007511.Peer-Reviewed Original ResearchMeSH KeywordsAgedCOVID-19COVID-19 TestingEthnicityFemaleHumansMiddle AgedOpioid-Related DisordersSARS-CoV-2ConceptsOpioid use disorderCOVID-19 testPrick testUse disordersCOVID-19Older aged participantsTesting measuresSaliva-based testThroat swab samplesCOVID-19 transmissionGreater proportionGreater riskSwab samplesAdverse effectsAged participantsTesting optionsDisadvantaged populationsRacial-ethnic minoritiesWhite participantsDemographic differencesDisordersHome ordersGreater rateTreatmentParticipants
2021
Methadone within prison and linkage to and retention in treatment upon community release for people with opioid use disorder in Kyrgyzstan: Evaluation of a national program
Bachireddy C, Shrestha R, Bromberg DJ, Azbel L, Kurmanalieva A, Wegman M, Shumskaya N, Rozanova J, Meyer JP, Altice FL. Methadone within prison and linkage to and retention in treatment upon community release for people with opioid use disorder in Kyrgyzstan: Evaluation of a national program. International Journal Of Drug Policy 2021, 101: 103558. PMID: 34915426, PMCID: PMC9998103, DOI: 10.1016/j.drugpo.2021.103558.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHIV InfectionsHumansKyrgyzstanMaleMethadoneOpioid-Related DisordersPrisonersPrisonsRetrospective StudiesSubstance Abuse, IntravenousConceptsHIV statusMean treatment durationOpioid use disorderPositive HIV statusDuration of treatmentMethadone doseHIV incidenceMethadone servicesMethadone treatmentIndependent correlatesHIV preventionUse disordersTreatment durationMethadoneNational programTreatmentHIVAdministrative dataCommunity releaseMonthsKyrgyz prisonsFirst evaluationIncarcerated peopleDurationReleaseDifferential impacts of COVID-19 across racial-ethnic identities in persons with opioid use disorder
Mistler CB, Sullivan MC, Copenhaver MM, Meyer JP, Roth AM, Shenoi SV, Edelman EJ, Wickersham JA, Shrestha R. Differential impacts of COVID-19 across racial-ethnic identities in persons with opioid use disorder. Journal Of Substance Use And Addiction Treatment 2021, 129: 108387. PMID: 34080555, PMCID: PMC8380664, DOI: 10.1016/j.jsat.2021.108387.Peer-Reviewed Original ResearchConceptsOpioid use disorderPublic health responseCOVID-19Use disordersHealth behaviorsNon-prescription drug useRacial-ethnic minoritiesCOVID-19-related impactsMental health statusHealth care accessSexual health behaviorsCOVID-19 testGreater financial burdenRace/ethnicitySample of peopleDirect adverse effectsDrug treatmentCare accessAlcohol consumptionDrug useHealth statusHealth responseHealth disparitiesRisk peopleCOVID-19 pandemic presentsPurposeful Fentanyl Use and Associated Factors among Opioid-Dependent People Who Inject Drugs
Chandra DK, Altice FL, Copenhaver MM, Zhou X, Didomizio E, Shrestha R. Purposeful Fentanyl Use and Associated Factors among Opioid-Dependent People Who Inject Drugs. Substance Use & Misuse 2021, 56: 979-987. PMID: 33769199, DOI: 10.1080/10826084.2021.1901931.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidConnecticutCross-Sectional StudiesFentanylHumansOpioid-Related DisordersPharmaceutical PreparationsSubstance Abuse, IntravenousConceptsOpioid-dependent PWIDFentanyl useOpioid-dependent peopleIndependent correlatesSevere depressionSex-related risk behaviorsMethadone-maintained patientsMultivariable logistic regressionOpioid-related mortalityRecent cocaine useCross-sectional surveySelf-reported drugMethadone dosageYoung PWIDDaily injectionsMethadone clinicsAssociated FactorsFentanyl exposureHigh prevalencePWIDSynthetic opioidsCocaine useYounger ageRisk behaviorsLogistic regressionThe Impact of COVID-19 on Access to HIV Prevention Services Among Opioid-Dependent Individuals
Mistler CB, Curley CM, Rosen AO, El-Krab R, Wickersham JA, Copenhaver MM, Khati A, Shrestha R. The Impact of COVID-19 on Access to HIV Prevention Services Among Opioid-Dependent Individuals. Journal Of Community Health 2021, 46: 960-966. PMID: 33770334, PMCID: PMC7996112, DOI: 10.1007/s10900-021-00979-0.Peer-Reviewed Original ResearchConceptsOpioid use disorderHIV prevention servicesSTI testingHIV counselorsPrEP prescriptionPrevention servicesCOVID-19Pre-exposure prophylaxis servicesOpioid use disorder treatmentCOVID-19 pandemicClean injection equipmentOpioid-dependent individualsOpioid-dependent peopleUse disorder treatmentInjection equipmentHIV testingInfection testingBlood testingHIV preventionUse disordersPWIDDisorder treatmentDoctor's appointmentAdverse effectsCase managers
2020
Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment
Copenhaver MM, Sanborn V, Shrestha R, Mistler C, Gunstad J. Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment. Journal Of Addictive Diseases 2020, 39: 166-174. PMID: 33047651, PMCID: PMC11395862, DOI: 10.1080/10550887.2020.1831129.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive DysfunctionFemaleHumansMaleMental Status and Dementia TestsMethadoneMiddle AgedOpiate Substitution TreatmentOpioid-Related DisordersSelf ReportConceptsMethadone maintenance therapyDrug treatmentNeurocognitive dysfunctionNeurocognitive impairmentOpioid use disorderPossible clinical utilityAccommodation of patientsNIH ToolboxSubjective cognitive dysfunctionMaintenance therapyObjective cognitive testingSpecific neurocognitive profileTreatment outcomesCognitive dysfunctionClinical utilityUse disordersBrief inventoryObjective test performanceDysfunctionCognitive testingCutoff scoreNeurocognitive profileTest batteryObjective performanceImpairmentEngagement in Harm Reduction Strategies After Suspected Fentanyl Contamination Among Opioid-Dependent Individuals
Mistler CB, Chandra DK, Copenhaver MM, Wickersham JA, Shrestha R. Engagement in Harm Reduction Strategies After Suspected Fentanyl Contamination Among Opioid-Dependent Individuals. Journal Of Community Health 2020, 46: 349-357. PMID: 32997253, PMCID: PMC7920905, DOI: 10.1007/s10900-020-00928-3.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCross-Sectional StudiesDrug OverdoseFemaleFentanylHarm ReductionHumansMaleNaloxoneOpioid-Related DisordersUnited StatesConceptsFentanyl contaminationHarm reduction strategiesOpioid-dependent PWIDHigh-risk populationOpioid-dependent individualsHarm reduction behaviorsMethadone maintenance programHarm reduction methodsOpioid-related overdosesOverdose death ratesCross-sectional surveyDrug use behaviorsHarm reduction measuresPWID engagementMultivariable analysisFentanyl exposureOpioid epidemicOverdose ratesSynthetic opioidsDeath ratePolysubstance usersIntervention strategiesDrugsEvidence-based understandingEpidemicCognitive profiles in persons with opioid use disorder enrolled in methadone treatment
Sanborn V, Gunstad J, Shrestha R, Mistler CB, Copenhaver MM. Cognitive profiles in persons with opioid use disorder enrolled in methadone treatment. Applied Neuropsychology Adult 2020, 29: 462-468. PMID: 32463730, PMCID: PMC7704535, DOI: 10.1080/23279095.2020.1769099.Peer-Reviewed Original ResearchConceptsCognitive profileUse disordersTests of attentionDistinct cognitive profilesCognitive impairmentIntact cognitive functionOpioid use disorderExecutive functionCognitive phenotypesNIH ToolboxSubstance use treatmentCognitive functionImpaired groupAlcohol fourTreatment programPoor treatment outcomesUse treatmentMethadone maintenance treatment programImpairmentMaintenance treatment programDisordersUnderlying structurePersonsTreatment outcomesMore time
2019
Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study
Shrestha R, Altice FL, Sibilio B, Ssenyonjo J, Copenhaver MM. Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study. Contemporary Clinical Trials 2019, 82: 77-84. PMID: 31229618, PMCID: PMC6639056, DOI: 10.1016/j.cct.2019.06.012.Peer-Reviewed Original ResearchConceptsBio-behavioral interventionHIV risk reductionOpioid-dependent peopleMethadone maintenance programPrEP adherenceHIV transmission risk reductionFirst prospective trialPre-exposure prophylaxisHIV prevention strategiesOngoing drug useRisk reductionBehavioral skills modelProspective trialSecondary outcomesPrimary outcomeRisk reduction outcomesHIV riskWeek 20Prevention strategiesUnmet needDrug useHybrid type IBio-behavioral approachProcess evaluationAdherence
2018
HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support
Shrestha R, Altice FL, Sibilio B, Copenhaver MM. HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support. Journal Of Community Health 2018, 44: 112-120. PMID: 30043195, PMCID: PMC6330145, DOI: 10.1007/s10900-018-0560-7.Peer-Reviewed Original ResearchConceptsOpioid-dependent individualsOpioid-dependent patientsHIV statusFamily/friendsSexual partnersHIV disclosureHIV sero-status disclosureRisk behaviorsHIV sero statusAntiretroviral therapy adherenceHigh-risk HIVRole of HIVMultivariable logistic regressionSubstance abuse treatment settingsHIV risk behaviorsInconsistent condom useMultiple sex partnersSocial supportHigh HIVSero statusHIV transmissionTherapy adherenceIndependent correlatesHIV riskHIV stigmaViral suppression among HIV-infected methadone-maintained patients: The role of ongoing injection drug use and adherence to antiretroviral therapy (ART)
Shrestha R, Copenhaver MM. Viral suppression among HIV-infected methadone-maintained patients: The role of ongoing injection drug use and adherence to antiretroviral therapy (ART). Addictive Behaviors 2018, 85: 88-93. PMID: 29879611, PMCID: PMC6337064, DOI: 10.1016/j.addbeh.2018.05.031.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyMethadone-maintained patientsOngoing injection drug useViral suppressionAntiretroviral therapyInjection drug useHIV risk behaviorsDrug useSelf-reported HIV risk behaviorsImproved virologic outcomesOptimal ART adherenceHigher CD4 countsSustained viral suppressionMultivariable logistic regressionVirologic outcomesCD4 countMaintenance therapyOptimal adherenceART adherenceHIV treatmentIndependent correlatesTreatment challengesRisk populationsPatientsHIVIntegrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study
Shrestha R, Altice FL, Karki P, Copenhaver MM. Integrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study. AIDS And Behavior 2018, 22: 2640-2649. PMID: 29582199, PMCID: PMC6051885, DOI: 10.1007/s10461-018-2099-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidBiobehavioral SciencesCondomsFeasibility StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMethadoneMiddle AgedMotivationOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CarePilot ProjectsPre-Exposure ProphylaxisProspective StudiesRisk Reduction BehaviorSexual BehaviorSexual PartnersSubstance Abuse, IntravenousConceptsPre-exposure prophylaxis adherenceSelf-reported PrEP adherenceSex-related risk behaviorsHIV risk reduction behaviorsBio-behavioral interventionPre-exposure prophylaxisProspective clinical trialsHigh-risk peopleHIV prevention interventionsHIV risk behaviorsPilot feasibility studyPost-intervention assessmentPrEP adherenceProphylaxis adherencePreliminary efficacyClinical trialsIntervention groupHIV riskPrevention interventionsRisk behaviorsBio-behavioral approachAdherenceInterventionHigh acceptabilityPrEP
2017
Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment
Shrestha R, Karki P, Altice FL, Huedo-Medina TB, Meyer JP, Madden L, Copenhaver M. Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment. Drug And Alcohol Dependence 2017, 173: 107-116. PMID: 28214391, PMCID: PMC5366273, DOI: 10.1016/j.drugalcdep.2016.12.023.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisHIV risk reductionDrug injectionHIV riskRisk behaviorsHigh-risk drug usersHigh-risk PWUDOpioid-dependent personsHIV prevention approachesRecent risk behaviorsCross-sectional studyConsistent condom useHigh-risk behaviorsRisk reductionCorrelates of willingnessPrEP deliveryMethadone treatmentIndependent correlatesMethadone programsSafe drugElevated riskCasual partnersNeurocognitive impairmentDrug usersKey populationsA Moderated Mediation Model of HIV-Related Stigma, Depression, and Social Support on Health-Related Quality of Life among Incarcerated Malaysian Men with HIV and Opioid Dependence
Shrestha R, Copenhaver M, Bazazi AR, Huedo-Medina TB, Krishnan A, Altice FL. A Moderated Mediation Model of HIV-Related Stigma, Depression, and Social Support on Health-Related Quality of Life among Incarcerated Malaysian Men with HIV and Opioid Dependence. AIDS And Behavior 2017, 21: 1059-1069. PMID: 28108877, PMCID: PMC5344717, DOI: 10.1007/s10461-017-1693-x.Peer-Reviewed Original Research
2016
The Influence of Neurocognitive Impairment, Depression, and Alcohol Use Disorders on Health-Related Quality of Life among Incarcerated, HIV-Infected, Opioid Dependent Malaysian Men: A Moderated Mediation Analysis
Shrestha R, Weikum D, Copenhaver M, Altice FL. The Influence of Neurocognitive Impairment, Depression, and Alcohol Use Disorders on Health-Related Quality of Life among Incarcerated, HIV-Infected, Opioid Dependent Malaysian Men: A Moderated Mediation Analysis. AIDS And Behavior 2016, 21: 1070-1081. PMID: 27544515, PMCID: PMC5318281, DOI: 10.1007/s10461-016-1526-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderNeurocognitive impairmentUse disordersMalaysia's largest prisonHealth-related qualityNeuropsychological factorsQuality of lifeLargest prisonHIV-InfectedOpioid dependenceHIV treatmentHRQoLImportant negative predictorMeeting criteriaFuture interventionsDepressionNegative predictorPLWHDisordersMalaysian menStandardized scalesImpairmentMediation analysisHRQoL.HIV