2020
Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs
Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. Journal Of Substance Use And Addiction Treatment 2020, 117: 108058. PMID: 32811633, PMCID: PMC7438607, DOI: 10.1016/j.jsat.2020.108058.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisInjectable pre-exposure prophylaxisLAI-PrEPOral pre-exposure prophylaxisLong-term side effectsSelf-reported HIV risk behaviorsBangkok Tenofovir StudyEvidence-based HIVHigh-risk PWUDImportant key populationHIV-negative peopleOpioid use disorderHIV risk behaviorsHIV prevention effortsAddiction treatment programsDaily PrEPOral PrEPAdherence challengesIndependent correlatesFemale sexClinical trialsHIV preventionIndependent factorsSide effectsUse disorders
2018
Exploring the Use of Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among High-Risk People Who Use Drugs in Treatment
Shrestha R, Copenhaver M. Exploring the Use of Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among High-Risk People Who Use Drugs in Treatment. Frontiers In Public Health 2018, 6: 195. PMID: 30062091, PMCID: PMC6054971, DOI: 10.3389/fpubh.2018.00195.Peer-Reviewed Original ResearchPre-exposure prophylaxisPrEP adherenceHIV preventionHigh-risk PWUDSubstance abuse treatment settingsUse of PrEPHigh-risk peopleHIV risk behaviorsHIV prevention approachesPrEP servicesDaily dosingPrEP useHigh adherenceDepth semi-structured qualitative interviewsSemi-structured qualitative interviewsTreatment settingsPocket costsRisk behaviorsDisclosure statusPrEPAdherencePrevention approachesProphylaxisPreliminary evidencePWUD
2017
Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users
Shrestha R, Karki P, Altice FL, Dubov O, Fraenkel L, Huedo-Medina T, Copenhaver M. Measuring Acceptability and Preferences for Implementation of Pre-Exposure Prophylaxis (PrEP) Using Conjoint Analysis: An Application to Primary HIV Prevention Among High Risk Drug Users. AIDS And Behavior 2017, 22: 1228-1238. PMID: 28695388, PMCID: PMC5762432, DOI: 10.1007/s10461-017-1851-1.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisSex-related risk behaviorsHigh-risk drug usersAcceptability of PrEPHigh-risk PWUDPrimary HIV preventionHIV prevention approachesDrug treatment settingsKey risk populationsHIV-negative PWUDHigh acceptabilityHIV clinicPrEP acceptabilityHIV testingPrEP uptakeMethadone clinicsHIV preventionRisk populationsSide effectsTreatment settingsDrug usersPrEP attributesRisk behaviorsPrEPUnderserved populationsDeveloping an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research
Shrestha R, Altice F, Karki P, Copenhaver M. Developing an Integrated, Brief Biobehavioral HIV Prevention Intervention for High-Risk Drug Users in Treatment: The Process and Outcome of Formative Research. Frontiers In Immunology 2017, 8: 561. PMID: 28553295, PMCID: PMC5425476, DOI: 10.3389/fimmu.2017.00561.Peer-Reviewed Original ResearchNeurocognitive impairmentHigh-risk drug usersBehavioral interventionsHigh-risk PWUDHIV prevention behavioral interventionBiobehavioral approachHIV risk reductionHIV prevention interventionsDrug treatment settingsFormative researchHIV prevention effortsTarget populationPrEP adherencePrEP uptakeRisk reduction outcomesHIV preventionDrug treatmentPrevention interventionsFocus groupsTreatment settingsDrug usersRecovery programStructured focus groupsRisk behaviorsTarget population membersInterest in use of mHealth technology in HIV prevention and associated factors among high-risk drug users enrolled in methadone maintenance program
Shrestha R, Karki P, Copenhaver M. Interest in use of mHealth technology in HIV prevention and associated factors among high-risk drug users enrolled in methadone maintenance program. AIDS Care 2017, 29: 1144-1148. PMID: 28478706, PMCID: PMC6081193, DOI: 10.1080/09540121.2017.1325439.Peer-Reviewed Original ResearchConceptsHigh-risk PWUDMethadone maintenance programHIV preventionMedication remindersHIV risk reduction informationRisk behaviorsSex-related risk behaviorsHigh-risk drug usersMHealth technologiesHIV prevention toolHIV risk reductionHIV prevention approachesHIV risk behaviorsDrug treatment settingsRisk Behavior AssessmentHIV prevention effortsHIV-negative PWUDUse of mHealthNew intervention strategiesDepressive symptomsTreatment settingsDrug usersHealthcare providersMultivariate analysisPrevention effortsIntent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis
Shrestha R, Karki P, Huedo-Medina TB, Copenhaver M. Intent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis. Journal Of The Association Of Nurses In AIDS Care 2017, 28: 612-621. PMID: 28478870, PMCID: PMC7451137, DOI: 10.1016/j.jana.2017.04.005.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsNeurocognitive impairmentRisk behaviorsPreexposure prophylaxisSelf-reported neurocognitive symptomsHigh-risk drug usersHigh-risk PWUDPrEP uptakeNeurocognitive symptomsHIV riskDrug usersSimilar outcomesUnderserved populationsSignificant correlatesProphylaxisImportant unanswered questionsPreliminary evidencePrEPDissemination effortsMediation analysisUnanswered questionsVariables of interestHIVSymptomsCliniciansCorrelates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment
Shrestha R, Karki P, Altice FL, Huedo-Medina TB, Meyer JP, Madden L, Copenhaver M. Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment. Drug And Alcohol Dependence 2017, 173: 107-116. PMID: 28214391, PMCID: PMC5366273, DOI: 10.1016/j.drugalcdep.2016.12.023.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisHIV risk reductionDrug injectionHIV riskRisk behaviorsHigh-risk drug usersHigh-risk PWUDOpioid-dependent personsHIV prevention approachesRecent risk behaviorsCross-sectional studyConsistent condom useHigh-risk behaviorsRisk reductionCorrelates of willingnessPrEP deliveryMethadone treatmentIndependent correlatesMethadone programsSafe drugElevated riskCasual partnersNeurocognitive impairmentDrug usersKey populations
2016
Willingness to Use Pre-Exposure Prophylaxis (PrEP): An Empirical Test of the Information-Motivation-Behavioral Skills (IMB) Model among High-Risk Drug Users in Treatment
Shrestha R, Altice FL, Huedo-Medina TB, Karki P, Copenhaver M. Willingness to Use Pre-Exposure Prophylaxis (PrEP): An Empirical Test of the Information-Motivation-Behavioral Skills (IMB) Model among High-Risk Drug Users in Treatment. AIDS And Behavior 2016, 21: 1299-1308. PMID: 27990587, PMCID: PMC5380590, DOI: 10.1007/s10461-016-1650-0.Peer-Reviewed Original ResearchConceptsHigh-risk PWUDBehavioral skills modelCommunity-based methadone maintenance treatmentPre-exposure prophylaxis trialsSex-related HIV risk behaviorsHigh-risk drug usersPre-exposure prophylaxisIMB modelMethadone maintenance treatmentEfficacy of PrEPUse of PrEPHIV risk behaviorsKey risk populationsHealth behavior changeHIV acquisitionProphylaxis trialsHIV infectionMaintenance treatmentHIV preventionRisk populationsDrug usersRisk behaviorsPrEPPWUDIntervention developmentModeling a Theory-Based Approach to Examine the Influence of Neurocognitive Impairment on HIV Risk Reduction Behaviors Among Drug Users in Treatment
Huedo-Medina TB, Shrestha R, Copenhaver M. Modeling a Theory-Based Approach to Examine the Influence of Neurocognitive Impairment on HIV Risk Reduction Behaviors Among Drug Users in Treatment. AIDS And Behavior 2016, 20: 1646-1657. PMID: 27052845, PMCID: PMC4945437, DOI: 10.1007/s10461-016-1394-x.Peer-Reviewed Original ResearchConceptsNeurocognitive impairmentCommunity-based methadone maintenance treatmentHIV risk reduction informationSex-related HIV risk behaviorsHIV risk reduction behaviorsHigh-risk PWUDHIV prevention benefitsMethadone maintenance treatmentHIV prevention outcomesOpioid-dependent individualsSignificant neurocognitive impairmentHIV risk behaviorsHIV prevention behaviorsRisk reduction informationHealth behavior changeBehavioral skills modelRisk reduction behaviorsRisk reduction outcomesMaintenance treatmentEfficacious interventionsDrug usersPrevention benefitsPrevention outcomesPrevention behaviorsRisk behaviors