2021
Willingness to initiate pre-exposure prophylaxis (PrEP) and its use among opioid-dependent individuals in drug treatment
Ni Z, Altice FL, Wickersham JA, Copenhaver MM, DiDomizio EE, Nelson LE, Shrestha R. Willingness to initiate pre-exposure prophylaxis (PrEP) and its use among opioid-dependent individuals in drug treatment. Drug And Alcohol Dependence 2021, 219: 108477. PMID: 33422864, PMCID: PMC7946167, DOI: 10.1016/j.drugalcdep.2020.108477.Peer-Reviewed Original ResearchConceptsOpioid-dependent individualsPre-exposure prophylaxisPrEP useHIV riskHealthcare providersSex-related risk behaviorsMultivariable logistic regression analysisAwareness of PrEPUrban methadone clinicMultiple logistic regressionDisproportionate HIV burdenLogistic regression analysisCross-sectional surveyHIV burdenHIV infectionHIV testingIndependent correlatesMethadone clinicsDrug treatmentRisk behaviorsLogistic regressionPrEPPrevious useHigher likelihoodProphylaxisChapter 11 HIV pre-exposure prophylaxis for people who inject drugs
Shrestha R, McCoy-Redd B, Meyer J. Chapter 11 HIV pre-exposure prophylaxis for people who inject drugs. 2021, 223-236. DOI: 10.1016/b978-0-323-68328-9.00011-4.Peer-Reviewed Original ResearchHIV preventionEffective HIV prevention toolHigh-risk sexual networksHIV pre-exposure prophylaxisLimited clinical trial dataSubstance usePre-exposure prophylaxisHIV prevention toolClinical trial dataHarm reduction programsKey target populationSubstance use disordersPart of patientsTarget populationPrEP outcomesPreexposure prophylaxisMedication adherenceHIV riskUse disordersTrial dataPWIDSexual networksPrEPPrevention toolProphylaxis
2019
Use of Smartphone to Seek Sexual Health Information Online Among Malaysian Men Who Have Sex with Men (MSM): Implications for mHealth Intervention to Increase HIV Testing and Reduce HIV Risks
Shrestha R, Lim SH, Altice FL, Copenhaver M, Wickersham JA, Saifi R, Ab Halim MA, Naning H, Kamarulzaman A. Use of Smartphone to Seek Sexual Health Information Online Among Malaysian Men Who Have Sex with Men (MSM): Implications for mHealth Intervention to Increase HIV Testing and Reduce HIV Risks. Journal Of Community Health 2019, 45: 10-19. PMID: 31375976, PMCID: PMC6957731, DOI: 10.1007/s10900-019-00713-x.Peer-Reviewed Original ResearchConceptsSexual health informationHIV testingHealth informationOnline sexual health informationSexual partnersRecent HIV testingHigh-risk MSMHIV/STIsHIV risk behaviorsHIV prevention activitiesCross-sectional online surveyHealth Information OnlineMalaysian MSMSTI preventionIndependent correlatesGeosocial networking appsHIV riskMHealth interventionsMHealth strategiesMHealth toolsRisk behaviorsOlder ageLogistic regressionMSMPrevention activitiesRationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study
Shrestha R, Altice FL, Sibilio B, Ssenyonjo J, Copenhaver MM. Rationale and design of an integrated bio-behavioral approach to improve adherence to pre-exposure prophylaxis and HIV risk reduction among opioid-dependent people who use drugs: The CHRP-BB study. Contemporary Clinical Trials 2019, 82: 77-84. PMID: 31229618, PMCID: PMC6639056, DOI: 10.1016/j.cct.2019.06.012.Peer-Reviewed Original ResearchConceptsBio-behavioral interventionHIV risk reductionOpioid-dependent peopleMethadone maintenance programPrEP adherenceHIV transmission risk reductionFirst prospective trialPre-exposure prophylaxisHIV prevention strategiesOngoing drug useRisk reductionBehavioral skills modelProspective trialSecondary outcomesPrimary outcomeRisk reduction outcomesHIV riskWeek 20Prevention strategiesUnmet needDrug useHybrid type IBio-behavioral approachProcess evaluationAdherence
2018
HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support
Shrestha R, Altice FL, Sibilio B, Copenhaver MM. HIV Sero-Status Non-disclosure Among HIV-Infected Opioid-Dependent Individuals: The Roles of HIV-Related Stigma, Risk Behavior, and Social Support. Journal Of Community Health 2018, 44: 112-120. PMID: 30043195, PMCID: PMC6330145, DOI: 10.1007/s10900-018-0560-7.Peer-Reviewed Original ResearchConceptsOpioid-dependent individualsOpioid-dependent patientsHIV statusFamily/friendsSexual partnersHIV disclosureHIV sero-status disclosureRisk behaviorsHIV sero statusAntiretroviral therapy adherenceHigh-risk HIVRole of HIVMultivariable logistic regressionSubstance abuse treatment settingsHIV risk behaviorsInconsistent condom useMultiple sex partnersSocial supportHigh HIVSero statusHIV transmissionTherapy adherenceIndependent correlatesHIV riskHIV stigmaIntegrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study
Shrestha R, Altice FL, Karki P, Copenhaver MM. Integrated Bio-behavioral Approach to Improve Adherence to Pre-exposure Prophylaxis and Reduce HIV Risk in People Who Use Drugs: A Pilot Feasibility Study. AIDS And Behavior 2018, 22: 2640-2649. PMID: 29582199, PMCID: PMC6051885, DOI: 10.1007/s10461-018-2099-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidBiobehavioral SciencesCondomsFeasibility StudiesFemaleHIV InfectionsHumansMaleMedication AdherenceMethadoneMiddle AgedMotivationOpiate Substitution TreatmentOpioid-Related DisordersPatient Acceptance of Health CarePilot ProjectsPre-Exposure ProphylaxisProspective StudiesRisk Reduction BehaviorSexual BehaviorSexual PartnersSubstance Abuse, IntravenousConceptsPre-exposure prophylaxis adherenceSelf-reported PrEP adherenceSex-related risk behaviorsHIV risk reduction behaviorsBio-behavioral interventionPre-exposure prophylaxisProspective clinical trialsHigh-risk peopleHIV prevention interventionsHIV risk behaviorsPilot feasibility studyPost-intervention assessmentPrEP adherenceProphylaxis adherencePreliminary efficacyClinical trialsIntervention groupHIV riskPrevention interventionsRisk behaviorsBio-behavioral approachAdherenceInterventionHigh acceptabilityPrEP
2017
Intent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis
Shrestha R, Karki P, Huedo-Medina TB, Copenhaver M. Intent to Use Preexposure Prophylaxis (PrEP), HIV Risk Behaviors, and Self-Report Neurocognitive Symptoms by High-Risk Drug Users: A Mediation Analysis. Journal Of The Association Of Nurses In AIDS Care 2017, 28: 612-621. PMID: 28478870, PMCID: PMC7451137, DOI: 10.1016/j.jana.2017.04.005.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsNeurocognitive impairmentRisk behaviorsPreexposure prophylaxisSelf-reported neurocognitive symptomsHigh-risk drug usersHigh-risk PWUDPrEP uptakeNeurocognitive symptomsHIV riskDrug usersSimilar outcomesUnderserved populationsSignificant correlatesProphylaxisImportant unanswered questionsPreliminary evidencePrEPDissemination effortsMediation analysisUnanswered questionsVariables of interestHIVSymptomsCliniciansCorrelates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment
Shrestha R, Karki P, Altice FL, Huedo-Medina TB, Meyer JP, Madden L, Copenhaver M. Correlates of willingness to initiate pre-exposure prophylaxis and anticipation of practicing safer drug- and sex-related behaviors among high-risk drug users on methadone treatment. Drug And Alcohol Dependence 2017, 173: 107-116. PMID: 28214391, PMCID: PMC5366273, DOI: 10.1016/j.drugalcdep.2016.12.023.Peer-Reviewed Original ResearchConceptsPre-exposure prophylaxisHIV risk reductionDrug injectionHIV riskRisk behaviorsHigh-risk drug usersHigh-risk PWUDOpioid-dependent personsHIV prevention approachesRecent risk behaviorsCross-sectional studyConsistent condom useHigh-risk behaviorsRisk reductionCorrelates of willingnessPrEP deliveryMethadone treatmentIndependent correlatesMethadone programsSafe drugElevated riskCasual partnersNeurocognitive impairmentDrug usersKey populations
2016
Association Between Intimate Partner Violence Against Women and HIV-Risk Behaviors
Shrestha R, Copenhaver MM. Association Between Intimate Partner Violence Against Women and HIV-Risk Behaviors. Violence Against Women 2016, 22: 1621-1641. PMID: 26912296, PMCID: PMC5308057, DOI: 10.1177/1077801216628690.Peer-Reviewed Original ResearchConceptsHIV risk behaviorsIntimate partner violenceSignificant global health issueInconsistent condom useAdverse health outcomesSTIs/HIVMultiple sex partnersSafer sexual practicesGlobal health issueHIV infectionHIV riskPartner violenceHealth outcomesSex partnersCondom useDisproportionate burdenEffective interventionsHealth issuesWomenHIVSexual practicesInfectionPotential relationshipRiskThe Impact of Methadone Maintenance Treatment on HIV Risk Behaviors among High-Risk Injection Drug Users: A Systematic Review.
Karki P, Shrestha R, Huedo-Medina TB, Copenhaver M. The Impact of Methadone Maintenance Treatment on HIV Risk Behaviors among High-Risk Injection Drug Users: A Systematic Review. Evidence-based Medicine & Public Health 2016, 2 PMID: 27066590, PMCID: PMC4824190.Peer-Reviewed Original ResearchMethadone maintenance treatmentInjection drug usersSex-related risk behaviorsHIV risk behaviorsRisk behaviorsMaintenance treatmentDrug usersSystematic reviewHigh-risk injection drug usersFuture HIV prevention strategiesRisk Injection Drug UsersSex-related HIV risk behaviorsHigh-risk populationHIV prevention strategiesSignificant decreaseMultiple sex partnersPreventable drugHIV infectionTreatment adherenceHIV riskLower incidenceHigh riskPrevention strategiesSex partnersDrug use
2013
The Age of Initiation of Drug Use and Sexual Behavior May Influence Subsequent HIV Risk Behavior: A Systematic Review
Baldwin P, Shrestha R, Potrepka J, Copenhaver M. The Age of Initiation of Drug Use and Sexual Behavior May Influence Subsequent HIV Risk Behavior: A Systematic Review. International Scholarly Research Notices 2013, 2013: 976035. PMID: 24381791, PMCID: PMC3870609, DOI: 10.1155/2013/976035.Peer-Reviewed Original ResearchHIV risk behaviorsSubsequent HIV risk behaviorsHuman immunodeficiency virusInjection drug usersRisk behaviorsDrug useHIV risk reduction interventionsSubsequent HIV riskHigh-risk drug useRisk reduction interventionsUnprotected sexual activityHigh-risk behaviorsAge of initiationImmunodeficiency virusHIV riskDrug treatmentDrug usersReduction interventionsSystematic reviewSexual activitySexual behaviorEarly ageAgeDebutSpecific factors