2024
Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRace
2023
TAVR explant with aortic root replacement using a homograft for an aortic rupture.
Singh S, Vallabhajosyula P, Geirsson A, Assi R. TAVR explant with aortic root replacement using a homograft for an aortic rupture. Multimedia Manual Of Cardio-Thoracic Surgery 2023, 2023 PMID: 36644957, DOI: 10.1510/mmcts.2022.101.Peer-Reviewed Original ResearchConceptsLeft coronary buttonAortic ruptureCoronary buttonsAortic rootAortic root replacementTranscatheter aortic valve prosthesisAortic valve prosthesisTAVR explantRoot replacementMale presentingCase reportTranscatheter prosthesesValve prosthesisStent frameBovine pericardiumProsthesisRuptureHaemopericardiumPseudoaneurysmHomograftsPresenting
2022
Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly interventionCommentary: The first operative risk score for contemporary aortic arch surgery
Assi R, Geirsson A, Vallabhajosyula P. Commentary: The first operative risk score for contemporary aortic arch surgery. Journal Of Thoracic And Cardiovascular Surgery 2022, 167: 609-610. PMID: 35489833, DOI: 10.1016/j.jtcvs.2022.03.017.Commentaries, Editorials and Letters
2021
Surgery for aortic dissection: An international case for universal coverage?
Pichert M, Geirsson A, Assi R. Surgery for aortic dissection: An international case for universal coverage? Journal Of Cardiac Surgery 2021, 36: 2044-2044. PMID: 33682946, DOI: 10.1111/jocs.15455.Commentaries, Editorials and LettersThe relationship between cardiac surgeon experience and average patient risk profile: CA and NY statewide analysis
Weininger G, Einarsson A, Mori M, Brooks C, Shang M, Assi R, Vallabhajosyula P, Geirsson A. The relationship between cardiac surgeon experience and average patient risk profile: CA and NY statewide analysis. Journal Of Cardiac Surgery 2021, 36: 1189-1193. PMID: 33462886, DOI: 10.1111/jocs.15333.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery BypassCross-Sectional StudiesHumansNew YorkRisk AssessmentSurgeonsTreatment OutcomeConceptsLow-risk casesPatient outcomesCardiac surgeonsLow-risk coronary artery bypassSurgeon yearsMedian annual case volumeCoronary artery bypassPatient risk profileAnnual case volumeCross-sectional studyBetter patient outcomesRegression modelsLinear regression modelsCABG casesMedian surgeonArtery bypassMid-career surgeonsMortality ratioMedian numberSurgeon experienceOutcome dataCase volumeExperienced surgeonsMortality rateOnline registry
2020
Clinicopathologic Features of Tissue Granulomas in Transplant Recipients: A Single Center Study in a Nontuberculosis Endemic Region.
Nussbaum EZ, Patel KK, Assi R, Raad RA, Malinis M, Azar MM. Clinicopathologic Features of Tissue Granulomas in Transplant Recipients: A Single Center Study in a Nontuberculosis Endemic Region. Archives Of Pathology & Laboratory Medicine 2020, 145: 988-999. PMID: 33290524, DOI: 10.5858/arpa.2020-0271-oa.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBartonellaBiopsyCommunicable DiseasesConnecticutCytomegalovirusFemaleGranulomaHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedOrgan TransplantationPrevalenceRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTransplantation, HomologousTreatment OutcomeYoung AdultConceptsEpidemiologic risk factorsPresence of symptomsInfectious etiologyAsymptomatic patientsTransplant recipientsTissue granulomasClinicopathologic featuresRisk factorsAllogeneic hematopoietic stem cell transplant recipientsHematopoietic stem cell transplant recipientsStem cell transplant recipientsYale-New Haven HospitalCommon infectious etiologiesLarge transplant populationCell transplant recipientsSingle-center studyCryptogenic organizing pneumoniaNew Haven HospitalRoutine disease surveillancePaucity of literatureCytomegalovirus hepatitisPosttransplant specimensBiopsy indicationOrganizing pneumoniaTransplant patientsMidterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection
Bojko MM, Assi R, Bavaria JE, Suhail M, Habertheuer A, Hu RW, Harmon J, Milewski RK, Desai ND, Szeto WY, Vallabhajosyula P. Midterm outcomes and durability of sinus segment preservation compared with root replacement for acute type A aortic dissection. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 900-910.e2. PMID: 32620395, DOI: 10.1016/j.jtcvs.2020.04.064.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAgedAortic AneurysmAortic DissectionAortic ValveAortic Valve InsufficiencyBlood Vessel Prosthesis ImplantationCardiac Surgical ProceduresFemaleHumansMaleMiddle AgedPostoperative ComplicationsRecurrenceReoperationRetrospective StudiesRisk AssessmentRisk FactorsSinus of ValsalvaTime FactorsTreatment OutcomeConceptsAcute typeRoot replacementAortic dissectionAortic insufficiencyRoot repairCumulative incidenceReplacement groupPostoperative aortic insufficiencyProximal aortic reoperationsRoot replacement groupMultivariable Cox regressionSinus of ValsalvaLongitudinal mixed modelsAortic reoperationValsalva dimensionsMidterm outcomesRoot dilationCox regressionFunctional outcomeRisk factorsReoperationSinusInsufficiencyDissectionMixed effects models
2019
The optimal treatment strategy for secondary mitral regurgitation: a subject of ongoing debate
Petrus AHJ, Klautz RJM, De Bonis M, Langer F, Schäfers HJ, Wakasa S, Vahanian A, Obadia JF, Assi R, Acker M, Siepe M, Braun J. The optimal treatment strategy for secondary mitral regurgitation: a subject of ongoing debate. European Journal Of Cardio-Thoracic Surgery 2019, 56: 631-642. PMID: 31535695, DOI: 10.1093/ejcts/ezz238.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Techniques and outcomes of secondary open repair for chronic dissection after acute repair of type A aortic dissection.
Assi R, Bavaria JE, Desai ND. Techniques and outcomes of secondary open repair for chronic dissection after acute repair of type A aortic dissection. The Journal Of Cardiovascular Surgery 2018, 59: 759-766. PMID: 29943963, DOI: 10.23736/s0021-9509.18.10646-x.Peer-Reviewed Original ResearchConceptsAortic dissectionSecondary open repairThoraco-abdominal aortaDistal false lumenRisk of ruptureAcute TAADChronic dissectionAcceptable morbidityAcute typeAcute repairPrimary tearDistal aortaOpen repairAneurysmal dilatationFalse lumenDistal reoperationExperienced handsIndex operationProgressive degenerationSuccessful repairAortaDissectionHybrid procedureRepairReoperation
2015
Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature
Azar MM, Assi R, Patel N, Malinis MF. Fungal Mycotic Aneurysm of the Internal Carotid Artery Associated with Sphenoid Sinusitis in an Immunocompromised Patient: A Case Report and Review of the Literature. Mycopathologia 2015, 181: 425-433. PMID: 26687073, DOI: 10.1007/s11046-015-9975-1.Peer-Reviewed Case Reports and Technical NotesConceptsInternal carotid arteryFungal mycotic aneurysmsMycotic aneurysmSphenoid sinusitisICA aneurysmsSphenoid sinusEORTC/MSG criteriaInternal Carotid Artery AssociatedFungal sphenoid sinusitisLiposomal amphotericin B.Parent vessel sacrificeInvasive fungal infectionsDuration of antimicrobialsEffective antifungal therapyDevastating complicationSurgical debridementEndoscopic resectionAngioinvasive infectionVessel sacrificeCase reportAntifungal therapyCoil embolizationIdeal treatmentCavernous sinusCarotid arteryAdvanced age and disease predict lack of symptomatic improvement after endovascular iliac treatment in male veterans.
Assi R, Brownson KE, Hall MR, Kuwahara G, Vasilas P, Dardik A. Advanced age and disease predict lack of symptomatic improvement after endovascular iliac treatment in male veterans. The Yale Journal Of Biology And Medicine 2015, 88: 85-91. PMID: 25745377, PMCID: PMC4345543.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaFirst post-operative visitIliac artery occlusive diseaseArtery occlusive diseasePost-operative visitSymptomatic improvementLimb ischemiaStent placementOcclusive diseaseMale veteransVA Connecticut Healthcare SystemAnkle-brachial indexSuccessful endovascular procedureAdditional surgical interventionPatient-related factorsLong-term outcomesQuality of lifeIliac artery interventionsEndovascular angioplastyAngiographic successSecondary patencyDistal runoffArtery interventionSuccessful revascularizationEndovascular treatment
2014
The “Free” Right Internal Thoracic Artery: A Versatile and Durable Conduit
Assi R, Youssef SJ, Almarzooq Z, Al‐Raweshidy Y, Hashim PW, Geirsson A, Hashim SW. The “Free” Right Internal Thoracic Artery: A Versatile and Durable Conduit. Journal Of Cardiac Surgery 2014, 29: 609-615. PMID: 25040250, DOI: 10.1111/jocs.12396.Peer-Reviewed Original ResearchConceptsRight internal thoracic arteryInternal thoracic arteryThoracic arteryPatency ratesCoronary revascularizationCoronary systemFree graftSitu right internal thoracic arterySurvival ratePredominant targetDistal coronary vesselsSaphenous vein graftsAngiographic patency ratesRight coronary systemSternal nonunionPerioperative complicationsPerioperative mortalityPerioperative outcomesSymptomatic patientsConsecutive patientsDurable conduitVein graftsCoronary angiogramMyocardial infarctionExcellent patency
2013
Symptomatic Obstruction of the Brachiocephalic and Left Subclavian Arteries Obscured by Aortic Stenosis
Hashim PW, Assi R, Grecu L, Dardik A. Symptomatic Obstruction of the Brachiocephalic and Left Subclavian Arteries Obscured by Aortic Stenosis. Annals Of Vascular Surgery 2013, 28: 737.e1-737.e5. PMID: 24368183, DOI: 10.1016/j.avsg.2013.04.030.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAgedAngioplasty, BalloonAortic Valve StenosisArterial Occlusive DiseasesBrachiocephalic TrunkConstriction, PathologicDiagnostic ErrorsDizzinessFemaleHeart Valve Prosthesis ImplantationHemodynamicsHumansMuscle WeaknessPredictive Value of TestsStentsSubclavian Steal SyndromeSyncopeTreatment OutcomeUltrasonography, Doppler, ColorConceptsAortic stenosisLeft-sided weaknessAortic valve replacementArtery obstructionUncommon causeValve replacementSubclavian arterySymptomatic reliefCerebrovascular insufficiencyPatient's symptomsBrachiocephalic trunkClinical manifestationsSymptomatic obstructionVessel diseaseBrachiocephalic arteryDiagnostic challengeSubclavian obstructionUpper extremityStenosisObstructionBrachiocephalicArterySymptomsLightheadednessStentingMetabolic syndrome is associated with type II endoleak after endovascular abdominal aortic aneurysm repair
Hall MR, Protack CD, Assi R, Williams WT, Wong DJ, Lu D, Muhs BE, Dardik A. Metabolic syndrome is associated with type II endoleak after endovascular abdominal aortic aneurysm repair. Journal Of Vascular Surgery 2013, 59: 938-943. PMID: 24360238, PMCID: PMC3966942, DOI: 10.1016/j.jvs.2013.10.081.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Aneurysm, AbdominalAortographyBlood Vessel Prosthesis ImplantationEndoleakEndovascular ProceduresHumansKaplan-Meier EstimateMaleMetabolic SyndromeMiddle AgedRetrospective StudiesRisk FactorsTime FactorsTomography, X-Ray ComputedTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsEndovascular abdominal aortic aneurysm repairType II endoleakAbdominal aortic aneurysm repairAortic aneurysm repairBody mass indexAbdominal aortic aneurysmHigh-density lipoproteinAneurysm repairMetabolic syndromeMass indexAortic aneurysmSac expansionInfrarenal abdominal aortic aneurysmVeterans Affairs Connecticut Healthcare SystemAneurysm sac expansionDevelopment of endoleaksNon-MetS groupAcute kidney injurySerum high-density lipoproteinPerioperative myocardial infarctionEndoleak typeMetS factorsMore endoleaksKidney injuryRadiologic surveillance