2021
Resident memory T cells form during persistent antigen exposure leading to allograft rejection
Abou-Daya K, Tieu R, Zhao D, Rammal R, Sacirbegovic F, Williams A, Shlomchik W, Oberbarnscheidt M, Lakkis F. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. Science Immunology 2021, 6 PMID: 33741656, PMCID: PMC8103522, DOI: 10.1126/sciimmunol.abc8122.Peer-Reviewed Original ResearchConceptsMemory T cellsEffector T cellsT cellsAllograft rejectionAntigen-specificTissue-resident memory T cellsFunctional memory T cellsResident memory T cellsMouse model of kidney transplantationGrafted T cellsPersistent antigen exposureModel of kidney transplantationRenal transplant outcomesRetransplantation experimentsDiscovery of therapeutic targetsExhaustion markersSurface phenotypeAntigen exposureInterferon-gTransplant outcomesKidney transplantationCognate antigenMouse modelOrgan transplantationTransplantation
2019
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, Williams A, Landsittel D, Shlomchik W, Morelli A, Oberbarnscheidt M, Lakkis F. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. Journal Of Clinical Investigation 2019, 130: 287-294. PMID: 31763998, PMCID: PMC6934226, DOI: 10.1172/jci125773.Peer-Reviewed Original ResearchConceptsHost DCT cell responsesDonor antigensT cellsMHC-peptide complexesActivation of host T cellsAlloantigens to T cellsEffector T cell responsesCD8+ T cellsDonor MHC moleculesHost T cellsDifferentiation to effectorKidney transplant modelSecondary lymphoid organsSelf-MHC moleculesAntigen presentation pathwayAcute rejectionAllograft rejectionDendritic cellsIndirect presentationTransplantation modelAntigen presentationLymphoid organsPresentation pathwayIntravital microscopy
2016
Getting Down and Dirty
Tieu R, Lakkis F, Oberbarnscheidt M. Getting Down and Dirty. Transplantation 2016, 100: 2490-2491. PMID: 27861276, PMCID: PMC5120362, DOI: 10.1097/tp.0000000000001490.Peer-Reviewed Original Research
2013
GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea
Luo X, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L. GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Human Molecular Genetics 2013, 22: 3609-3623. PMID: 23666531, PMCID: PMC3749857, DOI: 10.1093/hmg/ddt212.Peer-Reviewed Original ResearchConceptsProsensory domainSpiral ganglion neuronsHDR syndromeMouse inner earShortened cochlear ductInner earSensorineural deafnessSurvival of spiral ganglion neuronsCochleovestibular ganglionIncreased cell deathGenetic mapCochlear ductGATA3 functionAuditory system developmentHaplo-insufficiencyCell deathMolecular mechanismsFunctional studiesGanglion neuronsRenal diseaseConditional knockoutGATA3Mouse cochleaNeuronal survivalSyndrome