2023
Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15
Tieu R, Zeng Q, Zhao D, Zhang G, Feizi N, Manandhar P, Williams A, Popp B, Wood-Trageser M, Demetris A, Tso J, Johnson A, Kane L, Abou-Daya K, Shlomchik W, Oberbarnscheidt M, Lakkis F. Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15. Science Immunology 2023, 8: eadd8454. PMID: 37083450, PMCID: PMC10334460, DOI: 10.1126/sciimmunol.add8454.Peer-Reviewed Original ResearchConceptsAntigen persistenceIL-15Dendritic cellsT cellsAntigen presentationGraft-infiltrating dendritic cellsTissue-resident memory TCognate antigenAbsence of cognate antigenIL-15 transpresentationMemory T cell maintenanceT cell maintenanceChronic transplant rejectionKidney transplant modelIL-15 receptorAcute infection modelMemory TReceptor blockadeChronic rejectionTransplantation modelTransplant rejectionAcute infectionInterleukin-15Allograft pathologySterilizing immunity
2016
Getting Down and Dirty
Tieu R, Lakkis F, Oberbarnscheidt M. Getting Down and Dirty. Transplantation 2016, 100: 2490-2491. PMID: 27861276, PMCID: PMC5120362, DOI: 10.1097/tp.0000000000001490.Peer-Reviewed Original Research
2014
Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes
Luo X, Huang L, Han L, Luo Z, Hu F, Tieu R, Gan L. Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes. Schizophrenia Bulletin 2014, 40: 1285-1299. PMID: 24664977, PMCID: PMC4193716, DOI: 10.1093/schbul/sbu045.Peer-Reviewed Original ResearchConceptsCopy number variationsProtein-protein interactionsSchizophrenia susceptibility genesCandidate genesNumber variationsDisease-common variant hypothesisGlobal overview of genesProportion of missing heritabilityProtein-protein interaction dataSusceptibility genesAnalysis of copy number variationsIntegrated analysis of copy number variationsProtein products of genesIntegration of genesSchizophrenia-associated proteinsProducts of genesOverview of genesSchizophrenia candidate genesSchizophrenia risk genesVariant hypothesisTop genesGenetic heterogeneityFunctional characterizationRisk genesGenetic variants
2013
GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea
Luo X, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L. GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Human Molecular Genetics 2013, 22: 3609-3623. PMID: 23666531, PMCID: PMC3749857, DOI: 10.1093/hmg/ddt212.Peer-Reviewed Original ResearchConceptsProsensory domainSpiral ganglion neuronsHDR syndromeMouse inner earShortened cochlear ductInner earSensorineural deafnessSurvival of spiral ganglion neuronsCochleovestibular ganglionIncreased cell deathGenetic mapCochlear ductGATA3 functionAuditory system developmentHaplo-insufficiencyCell deathMolecular mechanismsFunctional studiesGanglion neuronsRenal diseaseConditional knockoutGATA3Mouse cochleaNeuronal survivalSyndrome