2021
Resident memory T cells form during persistent antigen exposure leading to allograft rejection
Abou-Daya K, Tieu R, Zhao D, Rammal R, Sacirbegovic F, Williams A, Shlomchik W, Oberbarnscheidt M, Lakkis F. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. Science Immunology 2021, 6 PMID: 33741656, PMCID: PMC8103522, DOI: 10.1126/sciimmunol.abc8122.Peer-Reviewed Original ResearchConceptsMemory T cellsEffector T cellsT cellsAllograft rejectionAntigen-specificTissue-resident memory T cellsFunctional memory T cellsResident memory T cellsMouse model of kidney transplantationGrafted T cellsPersistent antigen exposureModel of kidney transplantationRenal transplant outcomesRetransplantation experimentsDiscovery of therapeutic targetsExhaustion markersSurface phenotypeAntigen exposureInterferon-gTransplant outcomesKidney transplantationCognate antigenMouse modelOrgan transplantationTransplantation
2019
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, Williams A, Landsittel D, Shlomchik W, Morelli A, Oberbarnscheidt M, Lakkis F. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. Journal Of Clinical Investigation 2019, 130: 287-294. PMID: 31763998, PMCID: PMC6934226, DOI: 10.1172/jci125773.Peer-Reviewed Original ResearchConceptsHost DCT cell responsesDonor antigensT cellsMHC-peptide complexesActivation of host T cellsAlloantigens to T cellsEffector T cell responsesCD8+ T cellsDonor MHC moleculesHost T cellsDifferentiation to effectorKidney transplant modelSecondary lymphoid organsSelf-MHC moleculesAntigen presentation pathwayAcute rejectionAllograft rejectionDendritic cellsIndirect presentationTransplantation modelAntigen presentationLymphoid organsPresentation pathwayIntravital microscopy