2021
Resident memory T cells form during persistent antigen exposure leading to allograft rejection
Abou-Daya K, Tieu R, Zhao D, Rammal R, Sacirbegovic F, Williams A, Shlomchik W, Oberbarnscheidt M, Lakkis F. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. Science Immunology 2021, 6 PMID: 33741656, PMCID: PMC8103522, DOI: 10.1126/sciimmunol.abc8122.Peer-Reviewed Original ResearchConceptsMemory T cellsEffector T cellsT cellsAllograft rejectionAntigen-specificTissue-resident memory T cellsFunctional memory T cellsResident memory T cellsMouse model of kidney transplantationGrafted T cellsPersistent antigen exposureModel of kidney transplantationRenal transplant outcomesRetransplantation experimentsDiscovery of therapeutic targetsExhaustion markersSurface phenotypeAntigen exposureInterferon-gTransplant outcomesKidney transplantationCognate antigenMouse modelOrgan transplantationTransplantation
2020
Formation and function of resident memory t cells in renal allografts
Daya K, Zhao D, Tieu R, Rammal R, Oberbarnscheidt M, Lakkis F. Formation and function of resident memory t cells in renal allografts. The Journal Of Immunology 2020, 204: 161.24-161.24. DOI: 10.4049/jimmunol.204.supp.161.24.Peer-Reviewed Original ResearchOT-IT cellsEndogenous T-cell populationMouse kidney transplant modelOT-I T cellsResident memory T cellsMemory T cellsT cell populationsPreserved kidney functionKidney transplant modelTRM cellsAdoptive transferB6 recipientsTeff cellsChronic rejectionKidney allograftsRe-transplantationRenal allograftsNo significant differenceGraft histologyKidney graftsTransplantation modelBone marrowAllo groupKidney function