GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea
Luo X, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L. GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Human Molecular Genetics 2013, 22: 3609-3623. PMID: 23666531, PMCID: PMC3749857, DOI: 10.1093/hmg/ddt212.Peer-Reviewed Original ResearchConceptsProsensory domainSpiral ganglion neuronsHDR syndromeMouse inner earShortened cochlear ductInner earSensorineural deafnessSurvival of spiral ganglion neuronsCochleovestibular ganglionIncreased cell deathGenetic mapCochlear ductGATA3 functionAuditory system developmentHaplo-insufficiencyCell deathMolecular mechanismsFunctional studiesGanglion neuronsRenal diseaseConditional knockoutGATA3Mouse cochleaNeuronal survivalSyndrome