Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15
Tieu R, Zeng Q, Zhao D, Zhang G, Feizi N, Manandhar P, Williams A, Popp B, Wood-Trageser M, Demetris A, Tso J, Johnson A, Kane L, Abou-Daya K, Shlomchik W, Oberbarnscheidt M, Lakkis F. Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15. Science Immunology 2023, 8: eadd8454. PMID: 37083450, PMCID: PMC10334460, DOI: 10.1126/sciimmunol.add8454.Peer-Reviewed Original ResearchConceptsAntigen persistenceIL-15Dendritic cellsT cellsAntigen presentationGraft-infiltrating dendritic cellsTissue-resident memory TCognate antigenAbsence of cognate antigenIL-15 transpresentationMemory T cell maintenanceT cell maintenanceChronic transplant rejectionKidney transplant modelIL-15 receptorAcute infection modelMemory TReceptor blockadeChronic rejectionTransplantation modelTransplant rejectionAcute infectionInterleukin-15Allograft pathologySterilizing immunity